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CD82 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Duriez et al., Oncogene 2000
(Neoplasm Metastasis) :
Absence of
p53 dependent
induction of the metastatic suppressor
KAI1 gene after DNA damage
Mashimo et al., Biochem Biophys Res Commun 2000
(Lung Neoplasms...) :
These results suggest that the augmentation of the
KAI1 gene expression is independently
controlled by
p53 and c-Jun at the transcriptional level in the human cancer cell lines
Shinohara et al., Cancer Res 2001
(Lung Neoplasms) :
KAI1/CD82 has been shown to be a metastasis suppressor for several human cancers, and a recent study revealed that wild-type
tumor suppressor p53 can directly
activate KAI1/CD82 gene expression
Jackson et al., Urol Oncol 2002
(Prostatic Neoplasms...) :
Recently, identification of a sequence with homology to the consensus p53 binding motif in the promoter of the KAI1 metastasis suppressor gene, has led to a proposal that transcriptional regulation by
p53 controls expression of
KAI1 , and that a dramatic down-regulation of KAI1 mRNA levels in invasive tumors and many tumor cell lines, is directly due to loss of p53 function
Jackson et al., Prostate Cancer Prostatic Dis 2003
(Bone Neoplasms...) :
Recent data have proposed that transcription of the
KAI1 metastasis suppressor gene is directly
mediated by
p53 and that loss of KAI1 expression in advanced prostate cancer is simply due to loss of p53 function after mutation
Marreiros et al., Oncogene 2005
(Prostatic Neoplasms) :
KAI1 promoter activity is
dependent on
p53 , junB and AP2 : evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells
Mashimo et al., Proc Natl Acad Sci U S A 1998
(Neoplasm Metastasis...) :
The expression of the
KAI1 gene, a tumor metastasis suppressor, is directly
activated by
p53 ... We have found that the tumor suppressor gene
p53 can directly
activate the
KAI1 gene by interacting with the 5 ' upstream region