Gene interactions and pathways from curated databases and text-mining

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CD82 — TP53

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Duriez et al., Oncogene 2000 (Neoplasm Metastasis) : Absence of p53 dependent induction of the metastatic suppressor KAI1 gene after DNA damage
Mashimo et al., Biochem Biophys Res Commun 2000 (Lung Neoplasms...) : These results suggest that the augmentation of the KAI1 gene expression is independently controlled by p53 and c-Jun at the transcriptional level in the human cancer cell lines
Shinohara et al., Cancer Res 2001 (Lung Neoplasms) : KAI1/CD82 has been shown to be a metastasis suppressor for several human cancers, and a recent study revealed that wild-type tumor suppressor p53 can directly activate KAI1/CD82 gene expression
Jackson et al., Urol Oncol 2002 (Prostatic Neoplasms...) : Recently, identification of a sequence with homology to the consensus p53 binding motif in the promoter of the KAI1 metastasis suppressor gene, has led to a proposal that transcriptional regulation by p53 controls expression of KAI1 , and that a dramatic down-regulation of KAI1 mRNA levels in invasive tumors and many tumor cell lines, is directly due to loss of p53 function
Jackson et al., Prostate Cancer Prostatic Dis 2003 (Bone Neoplasms...) : Recent data have proposed that transcription of the KAI1 metastasis suppressor gene is directly mediated by p53 and that loss of KAI1 expression in advanced prostate cancer is simply due to loss of p53 function after mutation
Marreiros et al., Oncogene 2005 (Prostatic Neoplasms) : KAI1 promoter activity is dependent on p53 , junB and AP2 : evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells
Mashimo et al., Proc Natl Acad Sci U S A 1998 (Neoplasm Metastasis...) : The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53 ... We have found that the tumor suppressor gene p53 can directly activate the KAI1 gene by interacting with the 5 ' upstream region