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CDKN1A — NOTCH3

Text-mined interactions from Literome

Noseda et al., Mol Cell Biol 2004 : Activated Notch inhibits mitogen induced upregulation of p21Cip1 and delays cyclin D-cdk4 mediated Rb phosphorylation ... Notch dependent repression of p21Cip1 prevents nuclear localization of cyclin D and cdk4
Rooman et al., Am J Pathol 2006 (Metaplasia) : Chemical inhibition of Notch signaling resulted in increased proliferation and induction of the cell-cycle regulator p21Cip1
Henning et al., Cell Death Differ 2008 : Induction of the p21 ( cip/waf ) gene by activated Notch was mediated by increased binding of p53 to p53 binding sites in the p21 ( cip/waf ) promoter and was independent of the canonical RBP-J binding site
Heo et al., Growth Factors 2008 : Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing p21cip1/waf1 and p27kip1, which were blocked by the inhibition of Akt, mTOR and Notch
Ban et al., Cancer Res 2008 (Sarcoma, Ewing) : Conversely, forced expression of JAG1, activated NOTCH3 , or HEY1 induced p53 and p21 ( WAF1/CIP1 )
Cui et al., Cancer Res 2013 (Neoplasms) : This upregulation of Notch3 was required for the induction of p21 expression in senescent cells ... Downregulation of Notch3 led to a delayed onset of senescence and extended replicative lifespan, whereas adventitious expression of Notch3 was sufficient to activate senescence and p21 expression ... The ability of Notch3 to induce senescence and p21 expression was dependent on the canonical Notch singling ... The ability of Notch3 to induce senescence and p21 expression was dependent on the canonical Notch singling