Gene interactions and pathways from curated databases and text-mining

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CDKN1A — RAC1

Text-mined interactions from Literome

Dharmawardhane et al., Mol Biol Cell 2000 : p21 activated kinases (PAKs) are targets for activated Rac and Cdc42 guanosine 5'-triphosphatases and have been shown to regulate the actin-myosin cytoskeleton
Nisimoto et al., Eur J Biochem 2002 : Interaction between p21 activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid
Bao et al., Mol Cell Biol 2002 : Concomitant with our finding that the small GTPases Cdc42 and Rac1 were activated by attachment to FN, constitutively active ( ca ) Cdc42 and ca Rac1 promoted down-regulation of p21 ( CIP1 ) ... However, dominant negative ( dn ) Cdc42 and dn Rac1 mutants blocked the anchorage induced degradation of p21 ( CIP1 ), suggesting that an integrin induced Cdc42/Rac1 signaling pathway activates proteasomal degradation of p21 ( CIP1 )
Vidal et al., Blood 2002 : Cdc42/Rac1 dependent activation of the p21 activated kinase (PAK) regulates human platelet lamellipodia spreading : implication of the cortical-actin binding protein cortactin
Knight-Krajewski et al., Oncogene 2004 (Prostatic Neoplasms) : Inhibition of Rac1 induced p21 expression in androgen independent lines but had no effect on the higher p21 levels characteristic of LNCaP cells ... Conversely, overexpression of constitutively active Rac1 suppressed the higher p21 levels seen in LNCaP cells ... Thus, Rac1 activity is both necessary and sufficient for suppression of p21 in prostate cancer cells ... These results are unique in describing a role for Rac1 in p21 regulation and may implicate the Rac1 signaling pathway as a potential therapeutic target for controlling prostate cancer cell growth following progression to androgen independence
Yang et al., Biochem J 2008 (Breast Neoplasms) : Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK dependent induction of cyclin D1 and p21Cip1