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CDKN1A — RAC1
Text-mined interactions from Literome
Dharmawardhane et al., Mol Biol Cell 2000
:
p21 activated kinases (PAKs) are
targets for activated
Rac and Cdc42 guanosine 5'-triphosphatases and have been shown to regulate the actin-myosin cytoskeleton
Nisimoto et al., Eur J Biochem 2002
:
Interaction between
p21 activated protein kinase and
Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid
Bao et al., Mol Cell Biol 2002
:
Concomitant with our finding that the small GTPases Cdc42 and Rac1 were activated by attachment to FN, constitutively active ( ca ) Cdc42 and ca
Rac1 promoted down-regulation of
p21 ( CIP1 ) ... However, dominant negative ( dn ) Cdc42 and dn
Rac1 mutants
blocked the anchorage induced degradation of
p21 ( CIP1 ), suggesting that an integrin induced Cdc42/Rac1 signaling pathway activates proteasomal degradation of p21 ( CIP1 )
Vidal et al., Blood 2002
:
Cdc42/Rac1 dependent
activation of the
p21 activated kinase (PAK) regulates human platelet lamellipodia spreading : implication of the cortical-actin binding protein cortactin
Knight-Krajewski et al., Oncogene 2004
(Prostatic Neoplasms) :
Inhibition of
Rac1 induced
p21 expression in androgen independent lines but had no effect on the higher p21 levels characteristic of LNCaP cells ... Conversely, overexpression of constitutively active
Rac1 suppressed the higher
p21 levels seen in LNCaP cells ... Thus,
Rac1 activity is both
necessary and sufficient for suppression of
p21 in prostate cancer cells ... These results are unique in describing a
role for
Rac1 in
p21 regulation and may implicate the Rac1 signaling pathway as a potential therapeutic target for controlling prostate cancer cell growth following progression to androgen independence
Yang et al., Biochem J 2008
(Breast Neoplasms) :
Heregulin beta1 promotes breast cancer cell proliferation through
Rac/ERK dependent
induction of cyclin D1 and
p21Cip1