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CFL1 — PTEN
Text-mined interactions from Literome
Serezani et al., Science signaling 2012
(Candidiasis) :
PTEN directly
activates the actin depolymerization factor
cofilin-1 during PGE2 mediated inhibition of phagocytosis of fungi ... PGE ( 2 ) -dependent activation of
cofilin-1 was
mediated by the protein phosphatase activity of
PTEN ( phosphatase and tensin homolog deleted on chromosome 10 ), with which it directly associated
Vitolo et al., Oncogene 2013
:
Loss of
PTEN induces microtentacles through PI3K independent activation of
cofilin ...
PTEN loss and PI3K activation also
caused differential activation of the
cofilin regulators, LIM-kinase1 ( LIMK ) and Slingshot-1L ( SSH )