Gene interactions and pathways from curated databases and text-mining

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CPZ — PRL

Text-mined interactions from Literome

Tucker et al., J Clin Endocrinol Metab 1980 (Amenorrhea...) : One to 8 yr after successful surgery, the PRL increments after TRH and MCP were returning to normal, but the PRL responses to CPZ and ITT remained blunted
Spitz et al., Clin Endocrinol (Oxf) 1981 (Infertility, Male...) : The aim of the present study was to measure the PRL response to metoclopramide (MET) and chlorpromazine (CPZ) in seventeen patients with primary testicular failure and eight patients with isolated gonadotrophin deficiency ( IGD ) ... However, when compared with controls, the PRL response to both MET and CPZ as well as to TRH was exaggerated in primary testicular failure, whereas the responses wee decreased in IGD ... It is suggested that alterations in the steroid milieu are responsible for the exaggerated PRL response to MET, CPZ and TRH in primary testicular failure and the reduced response observed in IGD
Winters et al., Clin Endocrinol (Oxf) 1982 (Hypogonadism...) : The effect of chlorpromazine (CPZ) on prolactin (PRL) secretion was studied in fourteen sexually immature males ; nine with idiopathic hypogonadotrophic hypogonadism and five who proved to be normal early pubertal boys ... Treatment with human chorionic gonadotrophin ( hCG ) or testosterone enhanced the PRL response to CPZ in three of six hypogonadotrophic subjects ... These data indicate that lack of sex steroid exposure, rather than a more generalized hypothalamic disorder, explains the attenuated PRL response to CPZ found in untreated men with idiopathic hypogonadotrophic hypogonadism ... Moreover, CPZ stimulated PRL secretion may prove to be of practical value in distinguishing hypogonadotrophics from boys with delayed puberty
Rotrosen et al., Neurology 1980 (Disease Models, Animal...) : Unlike known dopamine antagonists, Q-CPZ does not alter dopamine turnover, cause prolactin release in vivo, or bind to dopamine/neuroleptic receptors in vitro
Okada et al., Acta Endocrinol (Copenh) 1978 (Hypopituitarism) : Eight patients ( group I ) showed normal PRL response to TRH and CPZ but TSH response to TRH was delayed in 4 of this group ... Twelve patients ( group II ) had normal ( 4 patients ) or higher ( 8 patients ) baseline PRL level and showed lower PRL response to CPZ than that to TRH ... Three patients ( group III ) had no PRL response to either TRH or CPZ