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CPZ — PRL
Text-mined interactions from Literome
Tucker et al., J Clin Endocrinol Metab 1980
(Amenorrhea...) :
One to 8 yr after successful surgery, the PRL increments after TRH and MCP were returning to normal, but the
PRL responses to
CPZ and ITT remained blunted
Spitz et al., Clin Endocrinol (Oxf) 1981
(Infertility, Male...) :
The aim of the present study was to measure the
PRL response to metoclopramide (MET) and
chlorpromazine (CPZ) in seventeen patients with primary testicular failure and eight patients with isolated gonadotrophin deficiency ( IGD ) ... However, when compared with controls, the
PRL response to both MET and
CPZ as well as to TRH was exaggerated in primary testicular failure, whereas the responses wee decreased in IGD ... It is suggested that alterations in the steroid milieu are responsible for the exaggerated
PRL response to MET,
CPZ and TRH in primary testicular failure and the reduced response observed in IGD
Winters et al., Clin Endocrinol (Oxf) 1982
(Hypogonadism...) :
The
effect of
chlorpromazine (CPZ) on
prolactin (PRL) secretion was studied in fourteen sexually immature males ; nine with idiopathic hypogonadotrophic hypogonadism and five who proved to be normal early pubertal boys ... Treatment with human chorionic gonadotrophin ( hCG ) or testosterone enhanced the
PRL response to
CPZ in three of six hypogonadotrophic subjects ... These data indicate that lack of sex steroid exposure, rather than a more generalized hypothalamic disorder, explains the attenuated
PRL response to
CPZ found in untreated men with idiopathic hypogonadotrophic hypogonadism ... Moreover,
CPZ stimulated
PRL secretion may prove to be of practical value in distinguishing hypogonadotrophics from boys with delayed puberty
Rotrosen et al., Neurology 1980
(Disease Models, Animal...) :
Unlike known dopamine antagonists,
Q-CPZ does not alter dopamine turnover,
cause prolactin release in vivo, or bind to dopamine/neuroleptic receptors in vitro
Okada et al., Acta Endocrinol (Copenh) 1978
(Hypopituitarism) :
Eight patients ( group I ) showed normal
PRL response to TRH and
CPZ but TSH response to TRH was delayed in 4 of this group ... Twelve patients ( group II ) had normal ( 4 patients ) or higher ( 8 patients ) baseline PRL level and showed lower
PRL response to
CPZ than that to TRH ... Three patients ( group III ) had no
PRL response to either TRH or
CPZ