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CREB1 — PGF

Text-mined interactions from Literome

Fukuyama et al., Biochem Biophys Res Commun 2005 (Hypertrophy) : We examined the role of CREB in PGF ( 2alpha ) -induced hypertrophy of VSMCs. PGF ( 2alpha ) induced phosphorylation of CREB at serine 133, which is a critical marker of activation, after 5-10min of stimulation in a dose dependent manner
Chang et al., Int Endod J 2010 (Second Messenger Systems) : PGF ( 2alpha ) induced both ERK and CREB/ATF-1 phosphorylation in pulp cells
Guo et al., Endocrinology 2012 : PGF2a increased COX-2 expression and CREB1 phosphorylation, which could be blocked by either the FP receptor antagonist AL8810 or PKC inhibitor Ro31-7549 ... A chromatin immunoprecipitation assay showed that the binding of CREB1 to the COX-2 promoter was increased by PGF2a and PMA in amnion fibroblasts ... In conclusion, we provide evidence that PGF2a induces COX-2 expression via the FP receptor and phosphorylates CREB1 by PKC, thus increasing CREB1 binding to the COX-2 promoter and the expression of COX-2 in human amnion fibroblasts