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CRKL — CXCL12
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of CBL-CRKL
→
CXCL12
(increases)
Chernock et al., Blood 2001
Evidence: In addition, SDF-1alpha stimulation enhanced the association of cbl with PI-3 kinase, Crk-L, and 14-3-3beta proteins.
-
OpenBEL Selventa BEL large corpus:
CRKL
→
CXCL12
(increases)
Wang et al., Blood 2000
Evidence: We observed that several other focal adhesion components, including focal adhesion kinase (FAK) and the adaptor molecules Crk and Crk-L, are phosphorylated on SDF-1alpha stimulation.
Text-mined interactions from Literome
Chernock et al., Blood 2001
:
In addition,
SDF-1alpha stimulation
enhanced the association of cbl with PI-3 kinase,
Crk-L , and 14-3-3beta proteins
Arai et al., Cell Signal 2006
:
SDF-1 stimulation induced tyrosine phosphorylation of CrkL, which was inhibited by the Src family kinase inhibitor PP1 or by dominant negative mutants of Lyn, thus indicating that Lyn mediated
SDF-1 induced phosphorylation of
CrkL