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CXCL12 — MMP13
Text-mined interactions from Literome
Yu et al., J Bone Miner Res 2003
(Bone Resorption) :
SDF-1 versus RANKL
effects on chemotaxis, transcollagen migration,
MMP-9 expression and activity, OC development, and bone resorption were evaluated in RAW cells or RAW-OCs
Chu et al., Oncogene 2007
(Carcinoma, Basal Cell...) :
Involvement of
matrix metalloproteinase-13 in
stromal-cell derived factor 1 alpha directed invasion of human basal cell carcinoma cells ... The transcriptional
regulation of
MMP-13 by
SDF-1alpha was mediated by phosphorylation of extracellular signal related kinase 1/2 and activation of the AP-1 component c-Jun
Ries et al., Blood 2007
(Inflammation) :
Moreover, the inflammatory cytokines TGF-beta1, IL-1beta, and TNF-alpha up-regulated MMP-2, MT1-MMP, and/or MMP-9 production in these cells, resulting in a strong stimulation of chemotactic migration through ECM, whereas the chemokine
SDF-1alpha exhibited minor
effects on
MMP/TIMP expression and cell invasion
Chiu et al., Mol Pharmacol 2007
(Arthritis, Rheumatoid...) :
Here, we found that
SDF-1alpha increased the secretion of
MMP-13 in cultured human chondrocytes, as shown by reverse transcriptase-polymerase chain reaction, Western blot, and zymographic analysis ... CXCR4 neutralizing antibody, CXCR4-specific inhibitor [ 1- [ [ 4- ( 1,4,8,11-tetrazacyclotetradec-1-ylmethyl ) phenyl ] methyl ] -1,4,8,11-tetrazacyclotetradecane ( AMD3100 ) ], or small interfering RNA against CXCR4 inhibited the
SDF-1alpha induced increase of
MMP-13 expression ... The transcriptional
regulation of
MMP-13 by
SDF-1alpha was mediated by phosphorylation of extracellular signal regulated kinases ( ERK ) and activation of the activator protein (AP)-1 components of c-Fos and c-Jun
Tan et al., Carcinogenesis 2008
(Carcinoma, Squamous Cell...) :
Again, U0126 almost
inhibited the induction of
MMP-13 in HEp-2 cells by stimulating
CXCL12 ... Blockage of c-Jun activity by transfection with c-jun antisense oligodeoxynucleotide significantly decreased
CXCL12 induced
MMP-13 expression and cell invasion
Laird et al., Hum Reprod 2011
:
Expression of
CXCL12 and CXCR4 in human endometrium ;
effects of CXCL12 on
MMP production by human endometrial cells ... The aim of this study was to investigate CXCL12 and CXCR4 expression in human endometrium and to see if
CXCL12 could
affect matrix metalloproteinase ( MMP ) production by endometrial stromal and epithelial cells