Motzkus et al., FASEB J 2006
(Sepsis) :
Moreover, DEFB123 prevented LPS induced tumor necrosis factor (TNF)-alpha secretion in a murine monocyte cell line ( RAW264.7 )
Semple et al., Eur J Immunol 2010
(Endotoxemia...) :
In addition, in the presence of LPS, hBD3 and the murine orthologue Defb14 ( but not hBD2 ), effectively inhibit TNF-alpha and IL-6 accumulation implying an anti-inflammatory function
Yu et al., J Biol Chem 2013
(Inflammation...) :
Interestingly, DEFB114 demonstrated novel LPS binding activity in vitro and inhibited TNF-a release in RAW264.7 cultures through the inhibition of MAPK p42/44 when challenged with LPS