◀ Back to CCNE1
CCNE1 — E2F2
Pathways - manually collected, often from reviews:
-
KEGG Cell cycle:
Complex of E2F1-E2F2-E2F3-TFDP1-TFDP2
→
CCNE1/CCNE2
(gene expression, expression)
-
NCI Pathway Database Regulation of retinoblastoma protein:
CDK2/Cyclin E1 complex (CDK2-CCNE1)
→
RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1)
(modification, activates)
Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
WikiPathways Retinoblastoma (RB) in Cancer:
Complex of TFDP1-E2F2
→
CCNE2/CDC25A/CCNE1/CCND3/CDK1/CCDC6/CCNB1
(mim-transcription-translation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
CCNE1
—
E2F2
(interaction, mapped from kegg_pathways)
-
STRING interaction:
E2F2
—
CCNE1
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
El Messaoudi et al., Proc Natl Acad Sci U S A 2006
:
E2F dependent regulation of the
CCNE1 promoter was shown to correlate with changes in the level of H3-K9 acetylation/methylation of nucleosomal histones positioned at the transcriptional start site region
Komatsu et al., Biochem Biophys Res Commun 2008
(Colonic Neoplasms) :
GeneChip and RT-PCR analyses revealed that troglitazone decreased mRNA levels of cell cycle regulatory factors E2F2 and
cyclin-E1 whose expression is
activated by
E2F2
Duronio et al., Genes Dev 1995
:
Instead,
cyclin E expression
activates E2F in the CNS
Chiarugi et al., Cell Mol Biol Res 1994
:
Notably, both of the two giant regulators of checkpoint 1 ( i.e., p105RB [ retinoblastoma oncosuppressor encoded protein ] and p53 dependent WAF1/CIP1 ) are influenced by or influence G1 cyclins :
cyclin E/cdk2 kinase complexes hyperphosphorylate p105RB,
induce E2F release, and free G1 exit