◀ Back to INS
ECM1 — INS
Text-mined interactions from Literome
Baricos et al., Experimental biology and medicine (Maywood, N.J.) 2003
:
In keeping with this observation, TGFbeta1 ( 1 ng/ml ) had no effect on ECM degradation by PAI-1-null MC. High glucose levels ( 30 mM ) in the presence or absence of
insulin ( 0.1 mM )
caused a moderate increase in
ECM degradation by normal human mesangial cells
Lee et al., Diabetes Obes Metab 2006
:
The direct
effect of
insulin on
ECM synthesis and degradation in glomerular mesangial cells ( GMCs ) is unclear
Mariappan et al., J Biol Chem 2008
(Diabetes Mellitus, Type 2...) :
Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high
insulin induced
extracellular matrix protein synthesis in renal proximal tubular epithelial cells
Lee et al., J Cell Physiol 2009
:
Our previous work has shown that
ECM affects
insulin signaling in mammary cells
Devi et al., Biochim Biophys Acta 2011
(Diabetic Retinopathy) :
We therefore examined the
effect of
insulin-like growth factor (IGF)-1 on
ECM/adhesion molecule expression, cell cycle regulation and monolayer permeability in an endothelial cell line ( TR-iBRB2 )
Gagnon et al., J Cell Physiol 1998
:
Since adipogenesis is an insulin/insulin-like growth factor-1 (IGF-1) dependent process, we investigated whether TGFbeta induced
ECM inhibits
insulin signaling ... Culturing 3T3-L1 preadipose cells on fibronectin, a component of the ECM induced by TGFbeta, also inhibited insulin dependent IRS-1 tyrosine phosphorylation and adipogenesis, supporting a
role for
ECM in mediating TGFbeta 's inhibitory effect on
insulin signaling