Gene interactions and pathways from curated databases and text-mining

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ECM1 — INS

Text-mined interactions from Literome

Baricos et al., Experimental biology and medicine (Maywood, N.J.) 2003 : In keeping with this observation, TGFbeta1 ( 1 ng/ml ) had no effect on ECM degradation by PAI-1-null MC. High glucose levels ( 30 mM ) in the presence or absence of insulin ( 0.1 mM ) caused a moderate increase in ECM degradation by normal human mesangial cells
Lee et al., Diabetes Obes Metab 2006 : The direct effect of insulin on ECM synthesis and degradation in glomerular mesangial cells ( GMCs ) is unclear
Mariappan et al., J Biol Chem 2008 (Diabetes Mellitus, Type 2...) : Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells
Lee et al., J Cell Physiol 2009 : Our previous work has shown that ECM affects insulin signaling in mammary cells
Devi et al., Biochim Biophys Acta 2011 (Diabetic Retinopathy) : We therefore examined the effect of insulin-like growth factor (IGF)-1 on ECM/adhesion molecule expression, cell cycle regulation and monolayer permeability in an endothelial cell line ( TR-iBRB2 )
Gagnon et al., J Cell Physiol 1998 : Since adipogenesis is an insulin/insulin-like growth factor-1 (IGF-1) dependent process, we investigated whether TGFbeta induced ECM inhibits insulin signaling ... Culturing 3T3-L1 preadipose cells on fibronectin, a component of the ECM induced by TGFbeta, also inhibited insulin dependent IRS-1 tyrosine phosphorylation and adipogenesis, supporting a role for ECM in mediating TGFbeta 's inhibitory effect on insulin signaling