◀ Back to HIF1A
EGR1 — HIF1A
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Liao et al., FASEB J 2007
:
These data suggest that although HIF-1alpha appears to dominate the PAI-1 transcriptional response in hypoxia,
Egr-1 and C/EBPalpha greatly augment this response and can do so
independent of
HIF-1alpha or each other
Sperandio et al., Mol Carcinog 2009
(Anoxia...) :
The transcription factor
Egr1 regulates the
HIF-1alpha gene during hypoxia
Tai et al., J Neurochem 2009
:
These findings are the first to suggest that hypoxia activates the proximal rat PNMT promoter primarily via
HIF1alpha induction of
Egr-1 and Sp1 rather than by co-activation by Egr-1, Sp1 and HIF1alpha
Patel et al., J Biol Chem 2010
(Anemia, Sickle Cell...) :
Additionally, the
Egr-1 mediated
induction of
HIF-1alpha and FLAP promoters was reduced to basal levels by EGR-1 small interfering RNA