◀ Back to IL1B
EGR1 — IL1B
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Giri et al., J Immunol 2003
:
Our results indicate that A beta induced expression of cytokines ( TNF-alpha and
IL-1 beta ) and chemokines ( MCP-1, IL-8, and MIP-1 beta ) in THP-1 monocytes
involves activation of ERK-1/ERK-2 and downstream activation of
Egr-1
Cheng et al., J Biol Chem 2004
(Inflammation) :
Electrophoretic mobility shift and supershift assays for Egr-1 binding sites in the mPGES-1 promoter showed that both 15d-PGJ ( 2 ) and TRO suppressed
IL-1beta induced DNA binding activity of
Egr-1
Peng et al., J Cell Physiol 2008
:
We reported previously that early
activation of
EGR-1 by
IL-1beta results in suppression of the proximal COL2A1 promoter activity by displacement of Sp1 from GC boxes
Sanchez-Guerrero et al., PloS one 2012
:
IL-1beta signals through the EGF receptor and
activates Egr-1 through MMP-ADAM ... Here we show that
Egr-1 expression
induced by
IL-1beta is dependent on metalloproteinases ( MMP ) and a disintegrin and a metalloproteinase ( ADAM ) ... Pharmacologic MMP/ADAM inhibitors and siRNA knockdown prevent
IL-1beta induction of
Egr-1 ... Further,
IL-1beta activates
Egr-1 via the epidermal growth factor receptor (EGFR) ...
IL-1beta induction of
Egr-1 expression is reduced in murine embryonic fibroblasts ( mEFs ) deficient in ADAM17 despite unbiased expression of EGFR and IL-1RI in ADAM17-deficient and wild-type mEFs ... This study reports for the first time that
Egr-1 induction by
IL-1beta involves EGFR and MMP/ADAM dependent EGFR phosphorylation
Chaudhary et al., Mol Cell Biochem 1996
:
Induction of
early growth response-1 gene by
interleukin-1 beta and tumor necrosis factor-alpha in normal human bone marrow stromal an osteoblastic cells : regulation by a protein kinase C inhibitor ... Our results demonstrate the expression of
Egr-1 gene and its
induction by
IL-1 beta , and TNF-alpha in normal human bone marrow stromal ( osteoprogenitor ) and osteoblastic cells in primary cultures ... Data also reveal that the expression of Egr-1 gene is inhibited by protein kinase C inhibitor H-7 suggesting that the activation of protein kinase C or other protein kinases resulting in the phosphorylation of specific transcription factor ( s ) is the first immediate early step in the
induction of immediate-early
Egr-1 gene by
IL-1 beta , and TNF-alpha