Gene interactions and pathways from curated databases and text-mining

◀ Back to CASP6

CASP6 — EIF4G1

Pathways - manually collected, often from reviews:

  • BioCarta internal ribosome entry pathway: Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10) → eIF-4G/eIF-4E/PTB complex (EIF4G1-EIF4G2-EIF4G3-EIF4E-PTBP1_PTBP2) (modification, activates)
  • BioCarta internal ribosome entry pathway: Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10) → eIF-4G/eIF3/EIF-4A complex (EIF4G1-EIF4G2-EIF4G3-EIF3S10-EIF4A1) (modification, activates)
  • BioCarta internal ribosome entry pathway: Active caspases (CASP5/CASP3/CASP4/CASP8/CASP1/CASP7/CASP6/CASP2/CASP9/CASP10) → c-Myc mRNA/eIF-4G (dimer)/eIF-3/eIF-4E/eIF-4A/PTB complex (EIF4A1-EIF4E-EIF3S10-EIF4G1-EIF4G2-EIF4G3-PTBP1_PTBP2) (modification, activates)

Text-mined interactions from Literome

Morley et al., FEBS Lett 2001 : Furthermore, MG132 also promotes the cleavage of eIF4G and the activation of caspase-3-like activity in a caspase-8-deficient Jurkat cell line which is resistant to anti-Fas mediated apoptosis
Marissen et al., Mol Cell Biol 1998 : In addition, purified caspase 3 caused cleavage of purified eIF4G , demonstrating that eIF4G could serve as a substrate for caspase 3