Gene interactions and pathways from curated databases and text-mining

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EPS15 — TNF

Text-mined interactions from Literome

Arena et al., Int Immunopharmacol 2006 : EPS-1 induced IL-12, IFN-gamma, IFN-alpha, TNF-alpha and IL-18, but not IL-4
Ma et al., Am J Chin Med 2009 (Arthritis, Gouty) : In addition, EPS ( 2.25, 4.5 g/kg, ig 9 days ) inhibited the expression of TNF-alpha and IL-1beta and the biological activity of NF-kappaB
Sheng et al., Appl Biochem Biotechnol 2011 : Tumor necrosis factor alpha ( TNF-a ), interferon-a ( IFN-? ), and interleukin-2 (IL-2) mRNA levels in splenocytes and thymocytes were increased after EPS treatment for 2, 4, 8, or 20 h. EPS also significantly elevated splenic TNF-a and IFN-? protein expressions at 100 µg/ml and increased thymic TNF-a and IFN-? protein levels at 50 and 100 µg/ml
Ciszek-Lenda et al., Int J Exp Pathol 2011 (Inflammation) : We also examined the relationship between TNF-a production and activation of mitogen activated protein kinases ( MAPKs ) by EPS and LPS