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EPS15 — TNF
Text-mined interactions from Literome
Arena et al., Int Immunopharmacol 2006
:
EPS-1 induced IL-12, IFN-gamma, IFN-alpha,
TNF-alpha and IL-18, but not IL-4
Ma et al., Am J Chin Med 2009
(Arthritis, Gouty) :
In addition,
EPS ( 2.25, 4.5 g/kg, ig 9 days )
inhibited the expression of
TNF-alpha and IL-1beta and the biological activity of NF-kappaB
Sheng et al., Appl Biochem Biotechnol 2011
:
Tumor necrosis factor alpha ( TNF-a ), interferon-a ( IFN-? ), and interleukin-2 (IL-2) mRNA levels in splenocytes and thymocytes were increased after EPS treatment for 2, 4, 8, or 20 h.
EPS also significantly elevated splenic TNF-a and IFN-? protein expressions at 100 µg/ml and
increased thymic
TNF-a and IFN-? protein levels at 50 and 100 µg/ml
Ciszek-Lenda et al., Int J Exp Pathol 2011
(Inflammation) :
We also examined the relationship between
TNF-a production and
activation of mitogen activated protein kinases ( MAPKs ) by
EPS and LPS