Hamadmad et al., J Pharmacol Exp Ther 2008
(Neoplasms) :
We show that Epo activates both pathways in a Janus kinase dependent manner and that this activation is required for Epo effects on cell migration
Okonko et al., Int J Cardiol 2013
(Anemia...) :
This is not due to EpoR downregulation but relates to a profound blunting of Epo induced JAK-STAT signalling
Kim et al., J Cell Biochem 2012
:
Recently, we demonstrated that Epo activates JAK/STAT signaling in hematopoietic stem cells ( HSCs ), leading to the production of bone morphogenetic protein 2 (BMP2) and bone formation and that Epo also directly activates mesenchymal cells to form osteoblasts in vitro