Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Tan et al., Cancer Res 2005 (Breast Neoplasms...) : Our studies revealed two novel mechanisms that are involved in Src protein up-regulation and activation by ErbB2 : ( a ) ErbB2 increased Src translation through activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway and ( b ) ErbB2 increased Src stability most likely through the inhibition of the calpain protease
Cinar et al., Cancer Res 2005 (Prostatic Neoplasms) : The signal to attenuate AR was mediated by the mammalian target of rapamycin , as shown by genetic and pharmacologic methods, and was independent of ErbB2/HER-2 , extracellular signal regulated kinase 1/2, and p38 mitogen activated protein kinase pathways
Mosley et al., Mol Cancer Ther 2007 (Hyperplasia...) : HER2/ErbB2 , in conjunction with ErbB3, signals through the Akt/phosphatidylinositol 3-kinase pathway and leads to the activation of mammalian target of rapamycin (mTOR) , a critical mRNA translation regulator that controls cell growth