◀ Back to STAT3
FGF1 — STAT3
Text-mined interactions from Literome
Udayakumar et al., Prostate 2004
(Prostatic Neoplasms) :
From these data, we conclude that
FGF-1 induces MT1-MMP expression in prostate carcinoma cells through a transcriptional mechanism mediated through the FGFR and the transcription factor,
STAT3
Ishikawa et al., Oncogene 2005
(Multiple Myeloma...) :
Furthermore, the
FGF induced activation of ERK 1/2
contributed to the serine phosphorylation of
STAT 3 , suggesting that the signaling crosstalk between the cytokine receptor, IL-6 receptor alpha/gp 130 and the growth factor receptor tyrosine kinase, FGFR 3
Zhang et al., Exp Eye Res 2005
:
Retinas from embryonic and neonatal stages showed that
STAT3 but not STAT1 was activated in
response to ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF),
fibroblast growth factor-1 (FGF1) , fibroblast growth factor-2 (FGF2), epidermal growth factor (EGF), interferon-alpha ( IFN-alpha ) and interferon-gamma (IFN-gamma) in distinct patterns ...
STAT3 activation was detected in the outermost retina layer in
response to CNTF, LIF,
FGF1 , and IFN-alpha 24 hr after stimulation in postnatal day 1 (PN1) explants, but not FGF2, EGF, IFN-gamma, and retinoic acid ( RA )
Li et al., Clin Cancer Res 2006
(Carcinoma, Hepatocellular...) :
In mice bearing orthotopically implanted HCCLM3,
STAT3 inhibition following therapeutic treatment with STAT3 ASO
reduced circulating vascular endothelial growth factor and basic
fibroblast growth factor , decreased intratumor CD34 positive microvessel density, intrahepatic and intraperitoneal transmission, and lung metastasis
Krejci et al., J Cell Sci 2008
:
However, as demonstrated by western blotting with phosphorylation-specific antibodies, imaging of STAT nuclear translocation, STAT transcription factor assays and STAT luciferase reporter assays,
FGF does not
activate STAT1 or
STAT3 in RCS chondrocytes, which nevertheless respond to a FGF stimulus with potent growth arrest
Cheranov et al., Blood 2008
:
14,15-EET induced the expression of vascular
endothelial cell growth factor ( VEGF ) in a time- and
Src-STAT-3 dependent manner in HDMVECs
Krejci et al., Cell Signal 2009
:
Despite the accumulation, both endogenous and cytokine induced activation of STAT1 and
STAT3 is
impaired by
FGF , as demonstrated by imaging of active STAT nuclear translocation and analyses of STAT activatory phosphorylation and transcriptional activation
Bhatnagar et al., J Biol Chem 2009
:
In contrast,
FGF-19 increased the activity of
STAT3 , an inhibitor of SREBP-1c expression and decreased the expression of peroxisome proliferator activated receptor-gamma coactivator-1beta ( PGC-1beta ), an activator of SREBP-1c activity