◀ Back to CDK2
CDK2 — FGF2
Text-mined interactions from Literome
Aikawa et al., J Biol Chem 2001
(Chondrosarcoma) :
In addition, the kinase activity of immunoprecipitated cyclin E or
Cdk2 , assessed with retinoblastoma protein ( pRb ) as substrate, was dramatically
reduced by
FGF-2
Kokkinakis et al., J Neuropathol Exp Neurol 2004
(Cell Transformation, Neoplastic) :
Western blot analyses demonstrated that MNU exposure caused progressive reduction of p21 protein levels, an increase of Rb phosphorylation,
activation of AKT and
CDK2 , and upregulation of
FGF receptors
Kolupaeva et al., Cell cycle (Georgetown, Tex.) 2012
:
In cells overexpressing cyclin D1/CDK4,
FGF induced downregulation of cyclin
E/CDK2 activity was absent
Murakami-Mori et al., J Immunol 1998
(Acquired Immunodeficiency Syndrome...) :
Endogenous
basic fibroblast growth factor is
essential for cyclin
E-CDK2 activity in multiple external cytokine induced proliferation of AIDS associated Kaposi 's sarcoma cells : dual control of AIDS associated Kaposi 's sarcoma cell growth and cyclin E-CDK2 activity by endogenous and external signals ... Thus,
FGF actions are
essential for cyclin
E-CDK2 activity and S phase entry