Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Aoki et al., Proc Natl Acad Sci U S A 2001 (Cell Transformation, Neoplastic) : Rapamycin inhibits the kinase mTOR , an important regulator of translation, and this inhibition requires binding of the antibiotic to the immunophilin FKBP12
Lawrence et al., Curr Top Microbiol Immunol 2004 : In contrast, rapamycin-FKBP12 inhibited mTOR activity towards both PHAS-I and p70S6K, although this complex inhibited the phosphorylation of some sites more than that of others
Oshiro et al., Genes Cells 2004 : Rapamycin, in the presence of FKBP12 , inhibited the association of raptor with mTOR directly in vitro, and concomitantly reduced the mTOR catalysed phosphorylation of raptor dependent, but not raptor independent substrates ; mTOR autophosphorylation was unaltered
Sarbassov et al., Curr Biol 2004 : Consistent with this finding, the rictor containing mTOR complex contains GbetaL but not raptor and it neither regulates the mTOR effector S6K1 nor is it bound by FKBP12-rapamycin
Hoeffer et al., Neuron 2008 (Synaptic Transmission) : Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
Martín-Cano et al., Aging 2013 : Mobilization of intracellular Ca2+ stores through IP3R or RyR channels was impaired in aged cells, and it was facilitated by mTOR and by FKBP12, as indicated by the inhibitory effects of KU0063794 ( a direct mTOR inhibitor ), rapamycin ( a FKBP12 mediated mTOR inhibitor ) and FK506 ( an FKBP12 binding immunosuppressant )