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FOXP3 — HNRNPH1
Text-mined interactions from Literome
Buckland et al., Am J Transplant 2006
:
Blocking ILT-3 or IL-12 does not diminish the capacity of these
DCs to
induce regulation or
Foxp3 expression on the regulatory T cells
Luo et al., Proc Natl Acad Sci U S A 2007
(Diabetes Mellitus, Type 1) :
Here we show that beta-cell peptide pulsed
dendritic cells (DCs) from nonobese diabetic ( NOD ) mice can effectively
induce CD4 ( + ) CD25 ( + )
Foxp3 ( + ) T cells from naïve islet-specific CD4 ( + ) CD25 ( - ) T cells in the presence of TGF-beta1 ... These results indicate a
role for
DCs in the induction of antigen-specific CD4 ( + ) CD25 ( + )
Foxp3 ( + ) T cells that can inhibit fully developed autoimmunity in a nonlymphopoenic host, providing an important potential strategy for immunotherapy in patients with autoimmune diabetes
Matsumura et al., J Immunol 2007
:
In this study, we demonstrated that suppressors of cytokine signaling (SOCS)-3-deficient DCs have a strong potential as
Foxp3 ( + ) T cell
inducing tolerogenic
DCs
Westendorf et al., Gut 2009
(Inflammatory Bowel Diseases) :
Although gut associated
DCs can
induce antigen-specific CD4 ( + )
Foxp3 ( + ) T cell proliferation, in vivo depletion of DCs did not preclude proliferation of these cells
Ganesh et al., Int Immunol 2009
(Thyroiditis, Autoimmune) :
Collectively, our results show that GM-CSF renders CD8a- DCs tolerogenic, and these
DCs induce
Foxp3+ and IL-10+ Tregs
Silva-Campa et al., Virology 2009
(Porcine Reproductive and Respiratory Syndrome) :
Our results showed that PRRSV infected
DCs significantly
increased Foxp3 ( + ) CD25 ( + ) T cells, an effect that was reversible by IFN-alpha treatment, and this outcome was reproducible using two distinct PRRSV strains
Brenk et al., J Immunol 2009
:
Moreover, ILT3 ( high ) ILT4 ( high )
DCs lead to the induction of CD4 ( + ) CD25 ( + )
Foxp3 ( + ) T regulatory cells with suppressive activity from CD4 ( + ) CD25 ( - ) T cells
Kushwah et al., J Immunol 2009
:
We have shown that in vitro culture of apoptotic DCs with immature DCs, results in their uptake by immature DCs, which subsequently turn into tolerogenic
DCs , which then secrete TGF-beta1 and
induce Foxp3 ( + ) regulatory T cells ( T ( regs ) )
Liu et al., J Cell Mol Med 2009
:
GXM pulsed
DCs increased the expression of
forkhead box P3 (Foxp3) in naïve human CD4 ( + ) CD25 ( - ) T cells via activating Fc gamma receptor IIb and activator protein-1 and promoting the expression of transforming growth factor beta in dendritic cells
Pothoven et al., Am J Transplant 2010
:
This work addresses whether rapamycin conditioned donor
DCs could effectively
induce CD4 ( + ) CD25 ( + )
Foxp3 ( + ) Tregs ( iTregs ) in cell cultures with alloantigen specificities, and whether such in vitro differentiated CD4 ( + ) CD25 ( + ) Foxp3 ( + ) iTregs could effectively control acute rejection in allogeneic islet transplantation
Fukaya et al., Methods Mol Biol 2011
:
Furthermore, antigen-specific generation of CD4 ( + )
Foxp3 ( + ) iT ( regs )
required the function of CD11 ( + )
DCs under steady-state conditions, whereas such conversion was severely abolished under inflammatory conditions
Worthington et al., Gastroenterology 2011
:
DCs that lack expression of integrin avß8 had reduced ability to activate latent TGF-ß and
induce Foxp3 ( + ) Tregs in vitro and in vivo
Agace et al., Trends Immunol 2012
:
Small intestine ( SI ) CD103 ( + )
DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and a4ß7 on responding T and B cells, and
enhance forkhead box P3 ( + ) T regulatory and IgA plasma cell differentiation in vitro
Zhao et al., Eur J Cancer 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
CML-MSC-DCs derived TGF-ß1 was largely
responsible for the increase in
CD4+CD25+Foxp3+Tregs based on knockdown studies
Cecere et al., Vet Microbiol 2012
(Coinfection...) :
DCs infected with PCV2 significantly
increased CD4 ( + ) CD25 ( + )
FoxP3 ( + ) T ( regs ) ( p < 0.05 ) and DCs co-infected with PRRSV and PCV2 induced significantly higher numbers of T ( regs ) than with PCV2 alone ( p < 0.05 )
Ramos et al., J Leukoc Biol 2012
(Breast Neoplasms) :
In cancer,
DCs may
play a dysfunctional role in the induction of CD4 ( + ) CD25 ( + )
Foxp3 ( + ) Tregs, contributing to immune evasion
Cavatorta et al., Clinical and vaccine immunology : CVI 2012
:
Upon
stimulation with
DCs or the mitogen concanavalin A, a subset of the proliferating T cells expresses the regulatory T-cell ( Treg ) transcription factor
FoxP3
Olivar et al., J Immunol 2013
(Inflammation) :
Moreover, C4BP ( ß ( - ) ) -treated
DCs failed to enhance allogeneic T cell proliferation, impairing IFN-? production in these cells and, conversely,
promoting CD4 ( + ) CD127 ( low/neg ) CD25 ( high )
Foxp3 ( + ) T cells
Khare et al., J Immunol 2013
:
CD103 ( + )
DCs from tolerized mice efficiently
induced Foxp3 in cocultured naive CD4 ( + ) T cells but pDCs and lung macrophages failed to do so
Tsai et al., J Immunol 2013
(Diabetes Mellitus, Experimental) :
We expressed an I-Ea ( kloxP ) transgene in NOD mice and used cell type-specific I-E ablation to show that I-E expressing
DCs , but not B cells,
promote the generation of autoreactive CD4 ( + )
Foxp3 ( + ) regulatory T cells ( Tregs ) and their accumulation in the pancreas draining lymph nodes
Matsumoto et al., J Immunol 2013
(Disease Models, Animal...) :
The PKCI treated
DCs had a semimature phenotype, showing high production of IL-10, and efficiently
induced IL-10 producing T cells and functional
Foxp3 ( + ) regulatory T cells from naive CD4 ( + ) T cells, thus eliciting a strong immunosuppressive function