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FGF9 — FRS2

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGF9 → FRS2 (reaction) Ong et al., Mol Cell Biol 2000, Wong et al., Proc Natl Acad Sci U S A 2002, Fong et al., J Biol Chem 2003, Agazie et al., Oncogene 2003, Takeda et al., Clin Cancer Res 2007, Ahmed et al., Biochem J 2008, Dutt et al., Proc Natl Acad Sci U S A 2008, Cha et al., J Biol Chem 2009, Qing et al., J Clin Invest 2009, Turner et al., Nat Rev Cancer 2010, Bai et al., Cancer Res 2010, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Ong et al., Biochem Biophys Res Commun 1996, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998, Xu et al., J Biol Chem 1998, Raffioni et al., J Biol Chem 1998
• Reactome Reaction: FGF9 → FRS2 (indirect_complex) Ong et al., Mol Cell Biol 2000, Lax et al., Mol Cell 2002, Wu et al., Biol Chem 2003, Takeda et al., Clin Cancer Res 2007, Ahmed et al., Biochem J 2008, Gotoh et al., Cancer Sci 2008, Dutt et al., Proc Natl Acad Sci U S A 2008, Cha et al., J Biol Chem 2009, Qing et al., J Clin Invest 2009, Zhou et al., Cell Res 2009, Turner et al., Nat Rev Cancer 2010, Bai et al., Cancer Res 2010, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Ong et al., Biochem Biophys Res Commun 1996, Kouhara et al., Cell 1997, Hadari et al., Mol Cell Biol 1998, Xu et al., J Biol Chem 1998, Raffioni et al., J Biol Chem 1998

Text-mined interactions from Literome

Gotoh et al., Proc Natl Acad Sci U S A 2004 : Consistent with the critical role of FRS2alpha in FGF signaling, the level of activated extracellular signal regulated kinase in Frs2alpha ( 2F/2F ) embryos was significantly lower than that observed in wild-type embryos
Antoine et al., Biochem Biophys Res Commun 2007 (Drug-Induced Liver Injury...) : FGF9 induced an increased phosphorylation of Tyr436 of the fibroblast growth factor receptor substrate (FRS) 2 , while phosphorylation of Tyr196 which is required for efficient Grb2 recruitment remained unchanged
Zhou et al., Cell Res 2009 : Recent studies have shown that mitogen activated protein kinase ( MAPK ) phosphorylates serine and threonine residues in FRS2, negatively affecting FGF induced tyrosine phosphorylation ( PY ) of FRS2
Haling et al., Mol Biol Cell 2010 (MAP Kinase Signaling System) : This reduced threonine phosphorylation led to increased FGF induced tyrosine phosphorylation of FRS2alpha , thereby enhancing downstream signaling
Lin et al., International journal of biological sciences 2011 : FRS2a is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts
Huynh et al., J Hepatol 2012 (Carcinoma, Hepatocellular...) : Dovitinib inhibited basal expression and FGF induced phosphorylation of FGFR-1, FRS2-a and ERK1/2 ... Dovitinib inhibited basal expression and FGF induced phosphorylation of FGFR-1, FRS2-a and ERK1/2
Zhang et al., Circ Res 2012 : FRS2a mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity
Madakashira et al., Development 2012 : Frs2a enhances fibroblast growth factor mediated survival and differentiation in lens development
Hadari et al., Mol Cell Biol 1998 : Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor induced PC12 cell differentiation ... In this report, we demonstrate that FRS2 forms a complex with the N-terminal SH2 domain of the protein tyrosine phosphatase Shp2 in response to FGF stimulation