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GHRH — PRKACG

Text-mined interactions from Literome

Lei et al., J Tongji Med Univ 2000 (Adenoma...) : In order to investigate the relationship between abnormal intracellular signal transduction and tumorgenesis of human pituitary somatotrophinomas, the effects of protein kinase A (PKA) dependent growth hormone (GH) releasing hormone ( GHRH ) and protein kinase C ( PKC ) -dependent GH-releasing peptide ( GHRP-6 ) on cAMP production were observed by using cell culture and biochemical methods, and the expression of the gsp oncogene was detected by using PCR and direct sequence assay methods in 11 patients with human pituitary somatotrophinomas
Pombo et al., Horm Res 2001 : It is well established that binding of GHRH to its receptor leads to activation of protein kinase A (PKA)
Wong et al., Neuroendocrinology 1995 : Somatostatin ( SRIF) (1 nM ), the physiological GH-release inhibitor, suppressed the GH response to GRF without affecting the basal or GRF stimulated PKA activity ... In this case, SRIF also induced a small but significant inhibition of GRF stimulated PKA activity