Gene interactions and pathways from curated databases and text-mining

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GLI1 — PRKAR1B

Text-mined interactions from Literome

Kaesler et al., Biol Chem 2000 : It was found that PKA inhibits GLI1 transcriptional activity ... Mutation of Ser336 revealed that PKA could also stimulate GLI1 transcriptional activity ... Thus, our data demonstrate both negative and positive regulation of human GLI1 by PKA
Zeng et al., PloS one 2010 : We further show that activation of protein kinase A (PKA) efficiently inhibits ciliary localization of Gli2 and Gli3, but only moderately affects the ciliary localization of Gli1