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EGF — GPER1

Text-mined interactions from Literome

Filardo et al., Steroids 2008 (Breast Neoplasms...) : The molecular details surrounding GPR30 mediated release of proHB-EGF , the involvement of integrin beta1 as a signaling intermediary in estrogen dependent EGFR action, and the possible implications of these data for breast cancer progression are discussed herein
Albanito et al., Endocrinology 2008 (Breast Neoplasms) : Using as a model system SkBr3 and BT20 breast cancer cells lacking the classical ER, the regulation of GPR30 expression by 17beta-estradiol, the selective GPR30 ligand G-1, IGF-I, and epidermal growth factor (EGF) was evaluated ... Accordingly, EGF up-regulated GPR30 protein levels, which accumulated predominantly in the intracellular compartment
Vivacqua et al., Mol Endocrinol 2009 : G protein coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha positive cancer cells ... We demonstrate that epidermal growth factor (EGF) and TGF alpha transactivate the GPR30 promoter and accordingly up-regulate GPR30 mRNA and protein levels only in endometrial and tamoxifen-resistant breast cancer cells
Lappano et al., Breast Cancer Res 2012 (Breast Neoplasms...) : Moreover, GPER was required for epidermal growth factor receptor (EGFR) and ERK activation by EGF as ascertained by using MIBE and performing gene silencing experiments