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HIF1A — IGF1

Text-mined interactions from Literome

Feldser et al., Cancer Res 1999 : We demonstrate that insulin, insulin-like growth factor (IGF)-1 , and IGF-2 induce expression of HIF-1alpha , which is required for expression of genes encoding IGF-2, IGF binding protein (IGFBP)-2 and IGFBP-3
Treins et al., Mol Endocrinol 2005 : We show that IGF-I stimulates HIF-1alpha accumulation, HIF-1alpha nuclear translocation, and HIF-1 activity by regulation of HIF-1alpha expression through a posttranscriptional mechanism
Dimova et al., Thromb Haemost 2005 (MAP Kinase Signaling System...) : Furthermore, IGF-1 enhanced HIF-1alpha protein levels and HIF-1 DNA binding to each HRE, E4 and E5 as shown by EMSA ... Furthermore, IGF-1 enhanced HIF-1alpha protein levels and HIF-1 DNA binding to each HRE, E4 and E5 as shown by EMSA ... Inhibition of either the PI3K by LY294002 or ERK1/2 by U0126 reduced HIF-1alpha protein levels while both inhibitors together completely abolished the IGF-1 effect on HIF-1alpha ... Remarkably, transfection of HepG2 cells with vectors expressing a dominant negative PDK1 or the PKB inhibitor, TRB3, did not influence while dominant negative Raf inhibited the IGF-1 effect on HIF-1alpha
Treins et al., Biochem Biophys Res Commun 2006 : AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1 ... Moreover, AICAR and metformin inhibited the ability of insulin and IGF-1 to induce HIF-1alpha expression
Carroll et al., Cancer Res 2006 (Breast Neoplasms...) : To address this, we used small interfering RNA ( siRNA ) techniques to knockdown HIF-1alpha and/or HIF-2alpha expression in response to hypoxia, insulin-like growth factor (IGF)-I , or renal carcinoma cells expressing constitutively high basal levels of HIF-1alpha and/or HIF-2alpha due to loss of von Hippel-Lindau (VHL) function
Sutton et al., Oncogene 2007 : Taken together, our data suggest that although ERK1/2 signalling is important for HIF-1alpha induction and HIF-1 activity in response to IGF-1 , it is dispensable for the induction of HIF-1alpha and activation of HIF-1 in response to hypoxia
Jiang et al., J Exp Med 2007 (Cardiomyopathy, Hypertrophic...) : HIF-1alpha coimmunoprecipitates with a Cu chaperone for superoxide dismutase-1 ( CCS ), and gene silencing of CCS, but not superoxide dismutase-1, prevents IGF-1- or Cu-induced HIF-1alpha activation and VEGF expression
Yu et al., Wound Repair Regen 2007 (Diabetes Mellitus...) : The aim of our study was to examine whether the reduced levels of Igf-1 are responsible for the reduction in Hif-1alpha protein synthesis and activity in diabetic wounds ... We provide evidence that Igf-1 regulates Hif-1alpha protein synthesis and activity during wound repair
Gelse et al., Osteoarthritis Cartilage 2008 (Cartilage Diseases) : The functional role of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinase ( ERK ) signaling on BMP-2/IGF-1 induced HIF-1alpha expression was assessed in vitro by employing specific inhibitors
Thomas et al., Prostate 2009 (Prostatic Neoplasms) : Furthermore, HIF-1alpha suppression attenuated the serum deprivation mediated increase in Akt and IGF-IR activation
Tang et al., Acta Pharmacol Sin 2009 (Breast Neoplasms) : Dau significantly inhibited IGF-I induced HIF-1alpha protein expression but had no effect on HIF-1alpha mRNA expression ... Mechanistically, Dau suppressed IGF-I induced HIF-1alpha and VEGF protein expression mainly by blocking the activation of PI-3K/AKT/mTOR signaling pathway ... In addition, Dau reduced IGF-I induced HIF-1alpha protein accumulation by inhibiting its synthesis as well as by promoting its degradation
Tang et al., Int J Cancer 2010 (Breast Neoplasms...) : We tested whether bisphosphonates had any effects on hypoxia-inducible factor (HIF)-1alpha/vascular endothelial growth factor ( VEGF ) axis that plays a pivotal role in tumor angiogenesis, and our results showed that both pamidronate and clodronate significantly suppressed IGF-1 induced HIF-1alpha protein accumulation and VEGF expression in MCF-7 cells
Spirli et al., Hepatology 2010 (Cysts...) : Rapamycin inhibited IGF1 stimulated HIF1alpha accumulation and VEGF secretion in LCECs
Huang et al., J Neurosci 2010 (Synaptic Transmission) : Our results show that IGF-1 induced a time- and dose dependent increase in HIF-1alpha expression that was blocked by pretreatment with selective IGF-1 receptor antagonist, transcriptional inhibitor, and translational inhibitors ... In addition, pharmacological blockade of the phosphatidylinositol 3-kinase/Akt/mammalian target of the rapamycin signaling pathway, but not extracellular signal regulated kinase, inhibited IGF-1 induced HIF-1alpha expression ... More importantly, the increase in HIF-1alpha expression induced by IGF-1 was accompanied by increasing levels of vascular endothelial growth factor ( VEGF ) mRNA and protein, which enhanced excitatory synaptic transmission
Gariboldi et al., Biochem Pharmacol 2010 (Glioblastoma) : Our results show that exogenous IGF-I causes IGF1R and STAT3 activation, and increases HIF1alpha protein levels and HIF1 trascriptional activity, inducing VEGF release ; a similar response, mediated by IGF-II release, is observed following HIF1alpha stabilization
Lawton et al., Oxidative medicine and cellular longevity 2010 : Hypoxia inducible factor-1 alpha ( HIF-1a ) regulates cell migration, signals through Notch, and is regulated by hypoxia/oxidative stress, insulin/IGF signaling, and factor inhibiting HIF-1a (FIH) hydroxylation
Zelzer et al., EMBO J 1998 : Finally, insulin-like growth factor-I (IGF-I) also induced the HIF-1alpha/ARNT transcription complex