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HMOX1 — IL10

Text-mined interactions from Literome

Lee et al., Nat Med 2002 : Here we show that, in murine macrophages, IL-10 induces expression of heme oxygenase-1 (HO-1) , a stress-inducible protein with potential anti-inflammatory effect, via a p38 mitogen activated protein kinase dependent pathway ... Induction of HO-1 by IL-10 was also evident in vivo
Petit-Bertron et al., J Leukoc Biol 2003 : Finally, heme oxygenase-1 , an anti-inflammatory molecule, was induced by IL-10 in adherent monocytes, whereas its expression remained low in nonadherent cells
Ricchetti et al., J Leukoc Biol 2004 (Inflammation) : Heme oxygenase 1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide ... IL-10 induced expression of HO-1 required the activation of signal transducer and activator of transcription ( STAT ) -3 but not p38 mitogen activated protein kinase ... In human macrophages, lipopolysaccharide inhibited HO-1 expression induced by IL-10 ... In summary, although IL-10 does regulate HO-1 expression, it does not appear to play a significant role in the anti-inflammatory activity of the cytokine
Ke et al., Hum Gene Ther 2007 (Reperfusion Injury) : This study analyzes how adenovirus ( Ad ) -based viral interleukin-10 ( vIL-10 ) gene transfer affects TLR4 and HO-1 signaling in host innate and adaptive immunity during liver IRI
Ito et al., Circ Res 2007 (Hypertension, Pulmonary) : In addition, IL-10 increased the lung level of heme oxygenase-1 , which strongly prevents PA remodeling
Xia et al., Am J Pathol 2007 (Asthma...) : Thus, we postulated that induction of HO-1 could augment IL-10 and transforming growth factor ( TGF ) -beta production and foxp3+CD4+CD25+ Treg cell function, thereby leading to attenuation of airway inflammation ... Up-regulation of HO-1 enhanced foxp3 expression and IL-10 secretion in the Treg cells in vitro
Zhao et al., Int Immunopharmacol 2008 : Corilagin also can promote HO-1 production to induce regression of inflammation but can inhibit IL-10 production like Dexamethasone
Koch et al., J Leukoc Biol 2009 (Inflammation) : Investigating potential underlying mechanisms, we found that IL-10 up-regulated the expression of complement regulatory membrane protein CD59 and the general cell-protective stress protein HO-1 in human monocytes
Mandal et al., Hepatology 2010 : Although IL-10 receptor surface expression on Kupffer cells was not affected by ethanol feeding, IL-10 mediated phosphorylation of STAT3 and expression of HO-1 was higher in Kupffer cells after ethanol feeding
Sierra-Filardi et al., Immunobiology 2010 (Melanoma...) : Heme Oxygenase-1 expression in M-CSF polarized M2 macrophages contributes to LPS induced IL-10 release
Gómez-Hurtado et al., Hepatology 2011 (Liver Cirrhosis...) : Unblocking IL-10 restored proinflammatory mediator and HO-1 expression to previously observed levels in response to LPS stimulation
Piantadosi et al., J Biol Chem 2011 (Sepsis) : HO-1 induction after LPS stimulated anti-inflammatory IL-10 and IL-1 receptor antagonist (IL-1Ra) expression in mouse liver, human HepG2 cells, and mouse J774.1 macrophages but blunted tumor necrosis factor-a expression
Lewkowicz et al., Immunobiology 2013 : We showed that LPS activated Treg cells promote generation of IL-10 and TGF-ß1, inhibit IL-6 production by PMNs and induce the expression of heme oxygenase-1 (HO-1) and the suppressor of cytokine signaling 3 molecule ( SOCS3 )
Lee et al., J Agric Food Chem 2013 (Diabetes Mellitus, Type 2) : It was found that monascin promoted heme oxygenase-1 (HO-1) expression mediated by Nrf2. Suppressions of AGEs, tumor necrosis factor-a (TNF-a), and interleukin-1ß ( IL-ß ) in serum of MG-induced rats were attenuated in the monascin administration group treated with retinoic acid ( RA )
Collino et al., Dis Model Mech 2013 (Disease Models, Animal...) : Besides, chronic HO-1 activation suppressed the elevated levels of myeloperoxidase (MPO) activity, interleukin 1ß (IL-1ß) production and tumor necrosis factor-a (TNFa) production that were evoked by the ischemic injury, and increased the plasma level of the anti-inflammatory cytokine IL-10 ... Besides, chronic HO-1 activation suppressed the elevated levels of myeloperoxidase (MPO) activity, interleukin 1ß (IL-1ß) production and tumor necrosis factor-a (TNFa) production that were evoked by the ischemic injury, and increased the plasma level of the anti-inflammatory cytokine IL-10
Das et al., J Antimicrob Chemother 2013 (Leishmaniasis, Visceral) : Furthermore, HO-1 blockade by miltefosine led to suppression of interleukin-10 and transforming growth factor-ß, but enhanced interleukin-12 and tumour necrosis factor-a production, in VL patients ... Furthermore, HO-1 blockade by miltefosine led to suppression of interleukin-10 and transforming growth factor-ß, but enhanced interleukin-12 and tumour necrosis factor-a production, in VL patients
Avdic et al., J Virol 2013 : Polarization of monocytes by viral IL-10 resulted in upregulation of HO-1, and inhibition of HO-1 function resulted in a loss of capacity of viral IL-10 to suppress tumor necrosis factor alpha ( TNF-a ) and IL-1ß, implicating HO-1 in viral IL-10 induced suppression of proinflammatory cytokines by M2c monocytes