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HSP90AA1 — IGF1

Text-mined interactions from Literome

Meares et al., FEBS Lett 2004 : Furthermore, with IGF-1 stimulation Hsp90 inhibition increased p38 activation, produced additive activation of p90RSK, and slightly increased the duration of ERK1/2 activation
Boehm et al., Arthritis Rheum 2007 : Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age dependent manner in equine articular chondrocytes ... The aim of this study was to investigate the roles of age and Hsp90 in insulin-like growth factor 1 (IGF-1) and interleukin-1beta (IL-1beta) signaling in chondrocytes
Lang et al., Clin Cancer Res 2007 (Neovascularization, Pathologic...) : Because insulin-like growth factor-I receptor ( IGF-IR ) and signal transducer and activator of transcription 3 ( STAT3 ) signaling pathways are implicated in the progression of pancreatic cancer, we hypothesized that blocking Hsp90 with geldanamycin derivates [ 17-allylamino-geldanamycin ( 17-AAG ), 17- ( dimethylaminoethylamino ) -17-demethoxygeldanamycin ( 17-DMAG ) ] would impair IGF-I- and interleukin-6 mediated signaling and thus reduce pancreatic tumor growth and angiogenesis in vivo
Ranganathan et al., Trends Pharmacol Sci 2010 (Motor Neuron Disease...) : Various therapeutic approaches have shown efficacy in mouse models, including androgen reduction, heat shock protein 90 (HSP90) inhibition and insulin-like growth factor (IGF)-1 overexpression