Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Gazitt et al., Int J Oncol 2009 (Bone Neoplasms...) : We used 17-AAG to inhibit Hsp90 and rapamycin to inhibit mTOR , in the osteosarcoma cell lines, HOS and KHOS/NP
Surova et al., Fiziolohichnyń≠ zhurnal (Kiev, Ukraine : 1994) 2009 : The changes of mRNA levels of genes of heat shock proteins HSP70 and HSP90 , antiapoptotic protein Bcl2 and key regulator of autophagy FRAP in cardiomyocytes culture were established
Shimamura et al., Cancer Res 2008 (Adenocarcinoma...) : In contrast, Hsp90 inhibition overcomes these limitations in vitro and depletes cells of EGFR, other RTKs, and phospho-Akt and inhibits mTOR signaling whether or not T790M is present
Delgoffe et al., Mol Immunol 2009 : Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation