Gene interactions and pathways from curated databases and text-mining

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CASP8 — ID3

Text-mined interactions from Literome

Koyama et al., Anticancer Res 2004 (Bone Neoplasms...) : Enforced expression of Id3 caused the MG-63 sarcoma cells to be more sensitive to CDDP induced growth inhibition, through generation of ROS and caspase-3 activation
Kee et al., J Immunol 2005 : We hypothesize that Id3 induces activation of caspase-2 as a consequence of severe or `` catastrophic '' growth arrest