Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Kusaba et al., J Biol Chem 2005 : Interleukin-12 induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR) ... In accordance with this, reduction in the mTOR protein level by small interfering RNA resulted in suppression of Stat3 phosphorylation and decreased production of IFN-gamma after IL-12 stimulation ... These results suggest that mTOR may play a major role in IL-12 induced IFN-gamma production by activated T cells
Wang et al., Circ Res 2007 (Coronary Artery Disease...) : We found that IFN-gamma mediated vascular smooth muscle cell proliferation and intimal expansion were associated with phosphorylation of the mTORC1 effector ribosomal protein S6 kinase 1, that the graft morphological changes and S6 kinase 1 activation were inhibited by the mTORC1 inhibitor rapamycin in vivo, and that IFN-gamma induced mTORC1 signaling was dependent on phosphatidylinositol 3-kinase activity under serum-free conditions in vitro