Gene interactions and pathways from curated databases and text-mining

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IFNG — VEGFA

Text-mined interactions from Literome

Kawano et al., Am J Reprod Immunol 2000 : Effects of interferon-gamma on secretion of vascular endothelial growth factor by endometrial stromal cells ... The aim of this study was to clarify the physiological effects of interferon (IFN)-gamma on secretion of vascular endothelial growth factor ( VEGF ) by endometrial stromal ( ES ) cells ... The effects of IFN-gamma on production of VEGF by ES cells were examined by analyzing VEGF mRNA expression with Northern blotting analysis and by assaying VEGF protein
Trompezinski et al., Exp Dermatol 2002 : In HF, the basal level of VEGF secretion was reduced by IFN-gamma and slightly increased by IL-4 whereas in HK, IFN-gamma enhanced the secretion of VEGF after 48 h and IL-4 either tended to reduce VEGF secretion or did not exert any effect ... Taken together, these results indicate opposite effects of IFN-gamma and IL-4 on VEGF expression from normal and activated HF and HK
Choi et al., Am J Reprod Immunol 2002 : These results suggest that IL-1beta, IFN-gamma , and TNF-alpha may regulate the production of VEGF in early gestational trophoblasts
Ramanathan et al., Experimental biology and medicine (Maywood, N.J.) 2003 (Anoxia) : Interferon-gamma (IFN-gamma) with Escherichia coli lipopolysaccharide (LPS) also upregulates expression of VEGF , as well as of the inducible nitric oxide synthase (iNOS) ... However, the iNOS inhibitor aminoguanidine ( AG ) decreases the VEGF expression induced by LPS/IFN-gamma , indicating an important role for NO ... LPS/IFN-gamma treatment induces minimal VEGF protein expression in macrophages cultured at low cell densities ( < 0.25 x 10 ( 6 ) cells/cm ( 2 ) ) ; at higher cell densities ( > 0.25 x 10 ( 6 ) cells/cm ( 2 ) ) that lead to conditions of pericellular hypoxia, however, induction of VEGF expression was strong ... Transient transfection of RAW 264.7 cells with luciferase reporter constructs of the murine VEGF promoter indicates that both hypoxia and LPS/IFN-gamma independently induce VEGF promoter activity, irrespective of cell density ... Although LPS/IFN-gamma treatment induces transcriptional activation of the VEGF promoter, significant levels of VEGF protein are only expressed by cells at high density under conditions of pericellular hypoxia ... Deletion analysis of the VEGF promoter shows that the hypoxia response element region and its immediate flanking sequences are essential for both hypoxia and LPS/IFN-gamma induced VEGF promoter activation
Mor et al., J Immunol 2004 (Anoxia...) : Indeed, VEGF augmented IFN-gamma and inhibited IL-10 secretion by T cells responding to mitogen or Ag ; thus, VEGF can enhance a Th1 phenotype
Malaguarnera et al., Int Immunopharmacol 2005 : Moreover, co-stimulation of PRL with LPS caused activation of HMMs functions, enhancement of HO-1 expression and induction of VEGF release, whereas addition of PRL inhibited up-regulation of HO-1 or VEGF induced by IFN-gamma or TNF-alpha
Battle et al., Cancer Res 2006 : IFN-gamma blocks the biological activity of VEGF through inhibition of genes necessary for the VEGF response, including angiopoietin-2, urokinase plasminogen activator, tissue inhibitor of matrix metalloproteinase-1, cyclooxygenase-2, and VEGF receptor 2
Cudmore et al., Circulation 2007 (Pre-Eclampsia) : Adenoviral overexpression of HO-1 in endothelial cells inhibited VEGF mediated sFlt-1 release and interferon-gamma- and tumor necrosis factor-alpha induced sEng release, whereas HO-1 inhibition potentiated sFlt-1 and sEng production from endothelial cells and placental villous explants
Jeon et al., Mol Cells 2007 : IFN-gamma , a potent cytokine, stimulated VEGF expression only in part through the PKA-CREB pathway
Ray et al., EMBO J 2007 : Although IFN-gamma induced persistent VEGF-A mRNA expression, translation was suppressed by delayed binding of the GAIT complex to a specific element delineated in the 3'UTR
Chen et al., Microcirculation 2008 (Dermatitis, Atopic...) : IL-6 and IFN-gamma stimulated VEGF-A mRNA production in the skin and in primary keratinocytes of transgenic mice ... In conclusion, IL-6 and IFN-gamma may play important roles in upregulation of VEGF-A , along with other pro-angiogenic factors, to induce dermal microvascular angiogenesis
Kommineni et al., Biochem Biophys Res Commun 2008 (Corneal Neovascularization) : TNF-alpha and IL-1 induced VEGF-A secretion by corneal fibroblasts ( HCRF ) and this was inhibited significantly by IFN-gamma ... IFN-gamma inhibited TGF-beta induced VEGF-A secretion but not sVEGF-R1 secretion ... This is the first report demonstrating the inhibitory and stimulatory effects of IFN-gamma on VEGF-A and sFlt-1 secretion, respectively
Sow et al., Dev Comp Immunol 2009 (Respiratory Distress Syndrome, Newborn...) : We report that VEGF induced the expression of chemokines ( IL-8, RANTES, MCP-1 ), cytokines ( IFN-gamma , IL-6, TNF-alpha, GMCSF ), Toll-like receptor (TLR)-4, complement family members ( C3, CFB, CFH ) and collectins ( SP-A, SP-D )
Bordin et al., Int J Oral Maxillofac Implants 2009 (Periodontitis) : Fibroblasts stimulated with TNF alpha showed increased levels of IL6, IL8, MCP1 ; neutrophil chemokine growth related oncogene alpha stimulation with IFN gamma increased MCP1 ; and stimulation with IL4 increased VEGF
Liu et al., Molecular vision 2010 : IFNgamma promoted human VEGF expression in both adult and fetal RPE cells ... The PI-3K/Akt/mTOR/p70 S6 kinase pathway is required for IFNgamma induced VEGF expression in retinal cells ... We provide evidence that IFNgamma induces VEGF expression in human retinal pigment epithelial cells ... Our work emphasizes that the activation of the PI-3K/mTOR/translational pathway is important for IFNgamma mediated VEGF expression in RPE cells
Gullick et al., PloS one 2010 (Arthritis, Rheumatoid...) : Finally, IL-17, but not IFNgamma , increased VEGF-A production by RA synovial fibroblasts in vitro
Xiong et al., Am J Pathol 1998 : In RAW cells, Ng-nitro-L-arginine-methyl ester and AG block IFNgamma/LPS activated , but not constitutive, VEGF production, whereas in MPMs, neither constitutive nor IFNgamma/LPS activated VEGF synthesis is affected
Dias et al., Int J Cancer 1998 (Mammary Neoplasms, Experimental...) : IFN-gamma reduced tumor cell production of VEGF over a 24-hr period in vitro, suggesting that IL-12 induced IFN-gamma may be responsible for the decline in VEGF levels in vivo