Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Patel et al., J Biol Chem 2002 : Insulin regulation of insulin-like growth factor binding protein-1 gene expression is dependent on the mammalian target of rapamycin , but independent of ribosomal S6 kinase activity
Martin et al., Biol Reprod 2003 : The resultant mTOR signaling could trigger polyamine, insulin-like growth factor II , and nitric oxide production in blastocysts and the increased cell motility sometimes associated with synthesis of these bioactive molecules
Erbay et al., J Cell Biol 2003 : IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients ... Here, we report the regulation of IGF-II transcription by mTOR , as well as by amino acid sufficiency, through the IGF-II promoter 3 and a downstream enhancer during C2C12 myoblast differentiation
Park et al., J Biol Chem 2005 : Previously we reported that the mammalian target of rapamycin (mTOR) regulates the initiation of the differentiation program in mouse C2C12 myoblasts by controlling the expression of insulin-like growth factor-II in a kinase independent manner
Ge et al., Am J Physiol Cell Physiol 2009 : Igf2 mRNA levels increase drastically during early regeneration, which is sensitive to rapamycin in wild-type muscles but partially resistant to rapamycin in both RR- and RR/KI-mTOR muscles, consistent with mTOR regulation of Igf2 expression in a kinase independent manner
Bhatia et al., Cell cycle (Georgetown, Tex.) 2010 (Medulloblastoma) : IGF activates the mammalian Target of Rapamycin (mTOR) , a growth promoting kinase normally kept in check by the tumor suppressive Tuberous Sclerosis Complex (TSC), comprised of TSC1 and TSC2
Burgos et al., Domest Anim Endocrinol 2010 : In addition, IGF-1 stimulated mTORC1 kinase activity toward 4E-BP1 in vitro
Ren et al., Proc Natl Acad Sci U S A 2010 (MAP Kinase Signaling System) : Hypoxia suppresses basal and IGF induced Akt-mTOR and p38 activity, whereas it enhances and prolongs IGF induced Erk1/2 activation in a HIF-1 dependent fashion
Ge et al., J Cell Biol 2011 : In addition, we provide evidence suggesting that miR-125b biogenesis is negatively controlled by kinase independent mammalian target of rapamycin (mTOR) signaling both in vitro and in vivo as a part of a dual mechanism by which mTOR regulates the production of IGF-II , a master switch governing the initiation of skeletal myogenesis
Ching et al., Exp Physiol 2013 : Likewise, IGF-1 stimulated phosphorylation of Akt S473, Akt T308, mTOR and S6K was lower in isolated soleus muscles from ATM ( +/- ) mice compared with muscles from ATM ( +/+ ) mice
Dai et al., Genes Dev 2013 : These findings uncover a new mechanism by which mTOR regulates organismal growth by promoting IGF2 production in the mouse embryo through mTORC2 catalyzed cotranslational IMP1/IMP3 phosphorylation
Melnik et al., Hautarzt 2013 (Acne Vulgaris...) : mTORC1 , the central hub of protein- and lipid biosynthesis, cell growth and proliferation, is activated by insulin, IGF-1 and branched-chain essential amino acids, especially leucine