UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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IKBKAP — PTGS2

Text-mined interactions from Literome

Chen et al., Mol Pharmacol 2001 : TNF-alpha- or C2-ceramide induced COX-2 promoter activity was inhibited by the dominant negative mutant of extracellular signal regulated kinase 2, p38, JNK, IkappaB kinase (IKK)1 , or IKK2
Chang et al., Mol Pharmacol 2004 : The dominant negative mutants of NIK and various IkappaB kinase complexes, including IKKbeta ( Y188F ), IKKbeta ( Y199F ), and IKKbeta ( FF ), inhibited the COX-2 promoter activity
Shih et al., Eur J Pharmacol 2009 : In this study, we investigated the involvement of the extracellular signal regulated kinase ( ERK ), IkappaB kinase alpha/beta ( IKKalpha/beta ), and nuclear factor-kappaB (NF-kappaB) signaling pathways in thrombin induced COX-2 expression in human lung fibroblasts ( WI-38 )