Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Baker et al., Mol Immunol 2009 : The results indicate that mTOR dependent IL-10 expression leads to inhibition of LPS induction of TF and the proinflammatory cytokine TNFalpha in WT macrophages
Weichhart et al., Immunity 2008 (Inflammation...) : Inhibition of mTOR by rapamycin promoted production of proinflammatory cytokines via the transcription factor NF-kappaB but blocked the release of interleukin-10 via the transcription factor STAT3
Cheekatla et al., Med Microbiol Immunol 2012 (Leishmaniasis, Visceral) : We show for the first time that in THP-1 derived macrophages and human monocytes, mTOR inhibition by rapamycin reversed L. donovani induced IL-12 and IL-10 modulation
Foldenauer et al., J Immunol 2013 (Keratitis...) : Because the mammalian target of rapamycin (mTOR) regulates IL-10 in other disease models, the present study tested its role in bacterial keratitis ... Collectively, these data, as well as a rescue experiment using rIL-10 together with rapamycin, which decreased PMN in cornea, provide concrete evidence that mTOR regulates IL-10 in P. aeruginosa induced bacterial keratitis and is critical to balancing pro- and anti-inflammatory events, resulting in better disease outcome
Ohtani et al., Blood 2008 (Leishmaniasis, Cutaneous) : Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide induced interleukin-12 production in dendritic cells