Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Mitra et al., Cytokine 2012 (Arthritis...) : In NHEK and FLS, IL-22 significantly induced phosphorylation of Akt and mTOR which was effectively blocked by Rapamycin and NVP-BEZ235
Ohtani et al., Blood 2008 (Leishmaniasis, Cutaneous) : Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide induced interleukin-12 production in dendritic cells
Datta Mitra et al., J Invest Dermatol 2013 (Psoriasis) : Interestingly, BE inhibited the IL-22 induced gene expression of AKT1, MTOR , chemokines [ IL-8 and RANTES ( regulated upon activation, normal T-cell expressed and secreted ) ], and psoriasin ( S100A7 ) more significantly than Vit-D