Gene interactions and pathways from curated databases and text-mining

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IL6 — NOX4

Text-mined interactions from Literome

Luchtefeld et al., Biochem Biophys Res Commun 2003 : Angiotensin II (ANG II) induced interleukin (IL)-6 synthesis requires NAD ( P ) H-oxidase derived superoxide anions
Yamagishi et al., J Mol Cell Cardiol 2004 : Pigment epithelium derived factor inhibits TNF-alpha induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase mediated reactive oxygen species generation ... The results demonstrated that PEDF inhibited TNF-alpha induced NF-kappaB activation and subsequent IL-6 overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation
Tojo et al., J Hypertens 2005 (Hypertension, Renal) : Nicotinamide adenine dinucleotide phosphate ( NAD ( P ) H ) oxidase is regulated by angiotensin II, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha via p38 mitogen activated protein kinase ( MAPK )
Yu et al., Int J Biochem Cell Biol 2005 : NADPH oxidase mediates interleukin-6 expression in cerulein stimulated pancreatic acinar cells ... We investigated whether pancreatic acinar cells contain NADPH oxidase, and whether NADPH oxidase mediates interleukin-6 (IL-6) in pancreatic acinar AR42J cells stimulated with cerulein ... NADPH oxidase inhibitor diphenylene iodonium ( DPI ), antioxidant rebamipide, and antisense oligonucleotides ( AS ODNs ) for NADPH oxidase subunits p22phox and p47phox were used to determine the involvement of NADPH oxidase in NF-kappaB activation and IL-6 expression in AR42J cells
Cheng et al., Am J Physiol Gastrointest Liver Physiol 2006 (Disease Models, Animal...) : In the circular muscle, PAF causes production of additional IL-6 that activates NADPH oxidase to induce production of H ( 2 ) O ( 2 )
Du et al., Biochem Biophys Res Commun 2007 : Although PAO was also reported to inhibit NADPH oxidase, the inhibition of NADPH oxidase by its specific inhibitor, diphenylene iodonium ( DPI ) could not suppress beta-AR mediated IL-6 production, suggesting that NADPH oxidase may not contribute to the inhibitory effect of PAO on IL-6 production
Turchan-Cholewo et al., Antioxid Redox Signal 2009 : Furthermore, inhibition of NADPH oxidase attenuated Tat induced release of interleukin-6 (IL-6) , tumor necrosis factor alpha (TNF), and monocyte chemoattractant protein 1 ( MCP-1 ), and decreased microglial mediated neurotoxicity
Behrens et al., J Neurosci 2008 (Disease Models, Animal) : Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia ... Here we show that neuronal production of interleukin-6 (IL-6) is necessary and sufficient for ketamine mediated activation of NADPH-oxidase in brain ... Our results showing that ketamine induced IL-6 is responsible for the activation of NADPH-oxidase in brain suggest that reducing brain levels of this cytokine may protect the GABAergic phenotype of fast spiking PV-interneurons and thus attenuate the propsychotic effects of ketamine
Zhang et al., Nephrology (Carlton) 2009 : Role of NAD ( P ) H oxidase in transforming growth factor-beta1 induced monocyte chemoattractant protein-1 and interleukin-6 expression in rat renal tubular epithelial cells ... This study investigated the role of NAD ( P ) H oxidase in transforming growth factor-beta1 ( TGF-beta1 ) -induced reactive oxygen species ( ROS ) generation, monocyte chemoattractant protein-1 ( MCP-1 ), and interleukin-6 (IL-6) expression in rat renal tubular epithelial NRK-52E cells
Lee et al., Cytokine 2010 : Additionally, pharmacological inhibitor of NADPH oxidase ( NOX ) significantly attenuated IL-4 induced ROS generation and IL-6 expression in HAEC
Tanabe et al., Journal of neuroinflammation 2010 (Glioma) : Apocynin, an inhibitor of NADPH oxidase that suppresses intracellular reactive oxygen species, significantly suppressed TNF-alpha induced IL-6 release and mRNA expression ... These results strongly suggest that TNF-alpha induces IL-6 synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells, and that phosphorylation of NFkappaB at Ser 536 and Ser 468, and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis
Li et al., J Innate Immun 2009 : NOX4 expression in human microglia leads to constitutive generation of reactive oxygen species and to constitutive IL-6 expression
Moe et al., J Cell Mol Med 2011 (Ventricular Remodeling) : Nox2 and Nox4 siRNA were used to determine whether or not Nox2 and Nox4 mediated TNF-a induced ROS and upregulation of IL-1ß and IL-6 in adult human cardiomyocytes ... Nox2 and Nox4 siRNA significantly attenuated TNF-a induced ROS and upregulation of IL-1ß and IL-6 in cardiomyocytes
Hopps et al., J Sports Med Phys Fitness 2011 (Obesity) : TNF-a and IL-6 , produced by adipose tissue, increase NADPH oxidase activity activating protein kinase C and NF?B leading to an higher oxidative stress
Donini et al., Prostate 2012 (Prostatic Neoplasms) : LNCaP enhance IL-1ß, IL-23, IL-6 , and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases IL-12 production through NADPH oxidase unrelated mechanisms
Fitzgerald et al., PloS one 2012 (Carcinoma, Renal Cell...) : Finally, we have characterized that enhanced levels of IL-6 and IL-8 result in RCC cell invasion and that activation of AMPK reduces Nox4 expression, IL-6 and IL-8 production, and RCC cell invasion