Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

MacManus et al., Mol Cancer Res 2007 (Prostatic Neoplasms) : Immunoblotting using phospho-specific antibodies confirmed that recombinant human IL-8 induced rapid time dependent phosphorylation of Akt and the mammalian target of rapamycin substrate proteins, 4E-BP1 and ribosomal S6 kinase, resulting in a downstream phosphorylation of the ribosomal S6 protein ( rS6 )
Ohtani et al., Blood 2008 (Leishmaniasis, Cutaneous) : Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide induced interleukin-12 production in dendritic cells
Narita et al., Science 2011 : mTOR recruitment to the TASCC was amino acid- and Rag guanosine triphosphatase dependent, and disruption of mTOR localization to the TASCC suppressed interleukin-6/8 synthesis
Britschgi et al., Cancer Cell 2012 (Breast Neoplasms...) : Mechanistically, PI3K/mTOR inhibition increased IRS1 dependent activation of JAK2/STAT5 and secretion of IL-8 in several cell lines and primary breast tumors