Gene interactions and pathways from curated databases and text-mining

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BCL2 — INS

Text-mined interactions from Literome

Ueno et al., Mol Biol Cell 2000 : Overexpression of IRS-1 suppresses phosphorylation of Bcl-2 induced by stimulation with insulin , and the hypophosphorylation may lead to its enhanced antiapoptotic activity
Iida et al., Arterioscler Thromb Vasc Biol 2002 : In the exploration of the signaling pathway involved in these antiapoptotic effects of insulin, pretreatment of cells with a specific inhibitor of phosphatidylinositol-3-kinase significantly suppressed insulin mediated cell survival and insulin induced Bcl-XL expression in macrophages
Augustin et al., Reproduction 2003 : No effects of insulin on the mRNA expression of Glut isoforms and Bax and Bcl-XL were found
Hui et al., Brain Res 2005 (Brain Ischemia) : In contrast, insulin , a PI3K agonist, not only obviously activated Akt1 during early and later reperfusion, but also inhibited phosphorylation of JNK1/2, c-Jun, and Bcl-2 and attenuated the activation of caspase-3
Jafari Anarkooli et al., Cell Mol Neurobiol 2009 (Body Weight...) : Effects of insulin and ascorbic acid on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of diabetic rats were evaluated in this study
Navarro et al., Exp Cell Res 1998 : Moreover, insulin down-regulated Bcl-xS expression without inducing the expression of Bcl-xL