Gene interactions and pathways from curated databases and text-mining

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CASP14 — IRF3

Text-mined interactions from Literome

Fantuzzi et al., Eur J Immunol 2001 : In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP
Suk et al., J Pharmacol Exp Ther 2003 : Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting caspase-11 activation, interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation
Santic et al., Cell Microbiol 2010 (Tularemia) : Initial sensing of F. tularensis in the cytosol triggers IRF-3 dependent IFN-beta secretion, type I IFNR dependent signalling, activation of the inflammasome mediated by caspase-1 , and a pro-inflammatory response, which is suppressed by triggering of SHIP
Moore et al., Virology 2011 : B10S-IRF3 expression augmented apoptotic caspase activation and decreased viral RNA in TMEV infected macrophages while SJL-IRF3 increased viral replication with less caspase activation