Gene interactions and pathways from curated databases and text-mining

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HIF1A — JUN

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Laderoute et al., Mol Cell Biol 2002 : Exposure of these mEFs to prolonged hypoxia demonstrated an absolute requirement for N-terminal sites for HIF-1 alpha dependent phosphorylation of c-Jun
Ding et al., J Biol Chem 2006 (Skin Neoplasms) : Exposure of cells to B [ a ] PDE and 5-MCDE did not induce HIF-1alpha activation, whereas AP-1 was significantly activated
Kim et al., Exp Cell Res 2007 (Bacterial Infections...) : The JNK signaling and c-Jun activation were required to induce the HIF-1alpha gene transcription by LPS