Gene interactions and pathways from curated databases and text-mining

◀ Back to FGF1

FGF1 — KL

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kurosu et al., J Biol Chem 2006 : To test the possibility that Klotho and FGF23 may function in a common signal transduction pathway ( s ), we investigated whether Klotho is involved in FGF signaling
Fukumoto et al., Bone 2007 (Hypophosphatemia) : Furthermore, FGF23 requires Klotho for its signaling in addition to a canonical FGF receptor
Mazzaferro et al., G Ital Nefrol 2009 (Chronic Disease...) : Interestingly, FGF23 has very low affinity for its receptor and requires the activity of Klotho , an anti aging gene, to become active
Château et al., Aging 2010 : Besides revealing a new post-developmental role for EGL-17, our data suggest that the KL1 form of Klotho is involved in FGF23 independent FGF signalling
Li et al., Mol Cell Endocrinol 2012 : In hepatocyte, FGF-21 up-regulation reduced HMGR and PEPCK mRNA expression and increased ß-klotho , FGFR4 and LDLr expression ( p < 0.05 ), whereas down-regulation had the opposite effects
Razzaque et al., Adv Exp Med Biol 2012 (Kidney Diseases) : Vitamin D can induce the expression of both FGF23 and klotho while, FGF23 can suppress renal expression of 1a ( OH ) ase to reduce 1,25 ( OH ) ( 2 ) D activity
Bhattacharyya et al., Trends Endocrinol Metab 2012 (Iron Metabolism Disorders...) : In physiologic states, FGF23 signaling is mediated by an FGF receptor and the coreceptor, Klotho