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KRAS — RASA1
Pathways - manually collected, often from reviews:
-
KEGG Axon guidance:
RASA1
→
HRAS/KRAS/NRAS
(protein-protein, inhibition)
-
KEGG MAPK signaling pathway:
RASA1
→
HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2
(protein-protein, inhibition)
-
NCI Pathway Database IL2-mediated signaling events:
RasGAP/Dok-R complex (RASA1-DOK2)
→
RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3)
(modification, inhibits)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
RasGAP/Dok-R complex (RASA1-DOK2)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, inhibits)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
SOCS3/RasGAP complex (SOCS3-RASA1)
→
RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3)
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
SOCS3/RasGAP complex (SOCS3-RASA1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/RasGAP complex (SHC1-RASA1)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Li et al., Science 1992, Stephens et al., Neuron 1994
Evidence: assay, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/RasGAP complex (SHC1-RASA1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Li et al., Science 1992, Stephens et al., Neuron 1994
Evidence: assay, other species
-
NCI Pathway Database Regulation of Ras family activation:
KRAS isoform 4B/GTP complex (KRAS)
→
RasGAP (RASA1)
(modification, collaborate)
Alvarez-Moya et al., Oncogene 2010*
Evidence: assay
-
NCI Pathway Database Regulation of Ras family activation:
RasGAP (RASA1)
→
KRAS isoform 4B/GDP complex (KRAS)
(modification, activates)
Alvarez-Moya et al., Oncogene 2010*
Evidence: assay
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Elowe et al., Mol Cell Biol 2001
Evidence: genetic interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Elowe et al., Mol Cell Biol 2001
Evidence: genetic interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
Evidence: assay
-
Reactome Reaction:
KRAS
→
RASA1
(reaction)
Nava et al., FEBS Lett 2000*, Shu et al., Mol Cell Biol 2002, Wu et al., Oncogene 2003*
-
Reactome Reaction:
KRAS
→
RASA1
(indirect_complex)
-
WikiPathways MAPK Signaling Pathway:
RASA1
→
MRAS/NRAS/KRAS
(mim-inhibition)
-
WikiPathways Rac1/Pak1/p38/MMP-2 pathway:
RASA1
→
HRAS/KRAS/NRAS
(inhibition)
Text-mined interactions from Literome
Hendron et al., Mol Biol Cell 2002
(MAP Kinase Signaling System) :
Renal A6 epithelial cells were used to determine whether induction of
Ki-ras leads to concomitant increases in the total as well as active levels of
Ki-RasA and whether this then leads to subsequent activation of its effector mitogen activated protein kinase ( MAPK/extracellular signal regulated kinase ) cascade
Wang et al., Int J Cancer 2003
(Colorectal Neoplasms) :
We found that the extrinsic GTPase activity of the codon 15 mutant
K-ras proteins ( p21 ( K-ras15M ) ) in the
presence of
GAP is much lower than that of the wild-type K-ras protein ( p21 BN ), whereas the intrinsic GTPase activity is nearly the same as that of the wild-type K-ras protein
Dasgupta et al., Cancer Res 2005
(Glioma...) :
Collectively, our results show that
K-RAS is the primary
target for neurofibromin
GTPase activating protein activity in vitro and in vivo and that K-RAS activation in astrocytes recapitulates the biochemical, biological, and tumorigenic properties of neurofibromin loss