Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Lynch et al., Am J Physiol Endocrinol Metab 2006 : In vitro, leptin secretion is regulated at the level of mRNA translation by the rapamycin-sensitive mammalian target of rapamycin (mTOR) and its agonist leucine ( Leu )
Cota et al., Science 2006 (Weight Loss) : The hormone leptin increases hypothalamic mTOR activity, and the inhibition of mTOR signaling blunts leptin 's anorectic effect
Szkudelski et al., Physiol Res 2007 : It is known that the activation of mTOR ( the mammalian target of rapamycin ) as well as increase in ATP and malonyl-CoA content in adipocytes enhance secretion of leptin ... The role of mTOR , ATP, cAMP, fatty acids, malonyl-CoA, adenosine and Ca ( 2+ ) in the regulation of leptin secretion from adipocytes is discussed
Maya-Monteiro et al., Cell cycle (Georgetown, Tex.) 2008 (Inflammation) : Important roles for mTOR on leptin signaling have been established both in hypothalamic centers to control food intake and in peripheral cells to regulate lipid metabolism and inflammation ... Leptin induced mTOR activation may have implications for obesity related pathophysiological conditions such as diabetes, cardiovascular disease and cancer
Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : Leptin mediated activation of mTOR ( mammalian target of Rapamycin ), mainly linked to MAPK, played a central role in leptin regulation of all cytokines and receptors
Villanueva et al., Endocrinology 2009 : Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status ... Leptin and feeding regulate the mammalian target of rapamycin complex 1 ( mTORC1 ) in the hypothalamus, and hypothalamic mTORC1 contributes to the control of feeding and energy balance ... In contrast, fasting and leptin deficiency suppress VMH mTORC1 signaling
Watterson et al., Neurosignals 2013 (Anorexia) : Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression ( anorexia )
Procaccini et al., J Immunol 2012 : Leptin induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses ... In this article, we show that leptin induced activation of mTOR , which, in turn, controls leptin production and signaling, causes a defined cellular, biochemical, and transcriptional signature that determine the outcome of Teff responses, both in vitro and in vivo