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IL6 — MAP3K7

Text-mined interactions from Literome

Kobayashi et al., J Biol Chem 2005 : Ser412 -- > Ala TAK1 also inhibited the forskolin induced up-regulation of interleukin 6 production in RAW264.7 cells treated with lipopolysaccharide
Kojima et al., Proc Natl Acad Sci U S A 2005 : STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6 stimulated TGFbeta activated kinase 1 for STAT3 Ser-727 phosphorylation ... Depletion of STAT3 diminished the IL-6 induced NLK activation by > 80 % without inhibiting IL-6 induced TAK1 activation or its nuclear entry
Frobøse et al., Mol Endocrinol 2006 : Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Thiefes et al., EMBO Rep 2006 : YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and interleukin-1-inducible activation of endogenous TAK1 , TAB1 and TAB2
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Kim et al., PloS one 2009 (Colitis) : Finally, we showed that TAK1 is essential for interleukin 1- and bacterial components induced expression of cytoprotective factors such as interleukin 6 and cycloxygenase 2
Fukuno et al., Biochem Biophys Res Commun 2011 : We also confirmed that TAK1 mediates cyclic stretch induced IL-6 protein synthesis in the cells using immunoblotting and ELISA
Hamidi et al., J Biol Chem 2012 (Inflammation) : Expression of a K34R-mutant TAK1 led to a reduced NF-?B activation, IL-6 promoter activity, and proinflammatory cytokine secretion by TNF-a stimulated PC-3U cells
Arcipowski et al., PloS one 2012 : We determined that TAK1 was required for JNK activation and interleukin-6 (IL-6) production mediated by CD40 and LMP1, in both mouse and human B cells