Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Hui et al., Mol Cell Biol 2004 : PLD1 stimulated increases in MDM2 expression and suppression of p53 activation were blocked by inhibition of mTOR and the mitogen activated protein kinase pathway
Pääjärvi et al., FASEB J 2005 (Liver Neoplasms) : Taken together, these data indicate that statins induce an mTOR dependent Ser166 phosphorylation of Mdm2 , and this effect may attenuate the duration and intensity of the p53 response to DNA damage in hepatocytes
Lyo et al., Biochem Biophys Res Commun 2010 (Kidney Neoplasms) : We report here that the PLD/mTOR dependent stabilization of HDM2 involves mTORC2 and the AGC family kinase serum- and glucocorticoid-inducible kinase 1 ( SGK1 )