Gene interactions and pathways from curated databases and text-mining

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IFNG — MIF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MIF → IFNG (increases)
    Evidence: Furthermore, it has been shown that MIF not only acts on macrophages, but it is also produced by these cells in response to endotoxins, exotoxins and cytokines such as TNF and interferon- [4] .

Text-mined interactions from Literome

Megid et al., Rev Inst Med Trop Sao Paulo 1999 (Rabies) : The survival of mice did not present correlation with the levels of antirabies serum neutralizing ( SN ) antibodies titers, IFN-gamma concentration and MIF response
Leech et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : Synoviocyte MIF was not increased by IL-1beta, TNFalpha, or IFNgamma
Rice et al., Nephrology (Carlton) 2003 : Interferon-gamma induces macrophage migration inhibitory factor synthesis and secretion by tubular epithelial cells ... In this study, we evaluated whether interferon-gamma (IFN-gamma) , a cytokine implicated in the development of kidney disease and a potent inducer of MIF production in macrophages, could promote MIF synthesis and secretion from renal tubular epithelial cells ... Following IFN-gamma stimulation, intracellular MIF in NRK52E cells was rapidly secreted with a maximal reduction of 50 % after 20 min, which returned to normal levels after 2-4 h. Rapid secretion of MIF in response to IFN-gamma was also seen in rat mesangial cells ... These findings indicate that IFN-gamma induces rapid secretion of MIF by tubular epithelial cells, and suggest that this may be an important mechanism leading to inflammatory cell accumulation and activation during kidney disease
Ohkawara et al., Immunol Lett 2006 (Colitis) : Lack of MIF suppressed the up-regulation of TNF-alpha and IFN-gamma as Th1 derived cytokines, and increased the level of IL-4 as Th2 derived cytokine in the colon tissues
Oki et al., Lymphokine Cytokine Res 1991 : The MIF activity in the culture supernatant of F5 cells was not due to contaminating interferon-gamma (IFN-gamma) , which is known to possess MIF activity
Thurman et al., J Immunol 1985 : These data indicate that MIF is really a family of cytokines that inhibit macrophage/monocyte migration and that the major portion of MIF activity associated with crude supernatant of mitogen stimulated lymphocytes is due to IFN-gamma
Herriott et al., J Immunol 1993 : MIF and IFN-gamma synergize with lipid A to mediate migration inhibition but only IFN-gamma induces production of TNF-alpha and nitric oxide
Calandra et al., J Exp Med 1994 : In RAW 264.7 macrophages, MIF secretion also was induced by tumor necrosis factor alpha (TNF-alpha) and IFN-gamma , but not by interleukins 1 beta or 6
Tesch et al., J Am Soc Nephrol 1998 (Glomerulonephritis) : Six-hour stimulation of mesangial cells with interferon-gamma or platelet derived growth factor significantly increased MIF mRNA levels