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MIF — TLR4
Text-mined interactions from Literome
Nishihira et al., Nihon rinsho. Japanese journal of clinical medicine 2004
(Sepsis) :
Recently, it was found that
Toll-like receptor 4 could be
regulated by
MIF , suggesting its involvement in the innate immunity
Ohkawara et al., Histochem Cell Biol 2006
:
In this study, we investigated the
effect of
MIF on the expression of
TLR4 , a receptor that recognizes lipopolysaccharide, in colon using MIF-deficient mice ... Our results suggest that
MIF affects the expression of
TLR4 in mouse colon under both normal and colitic conditions
Matsuda et al., Am J Respir Cell Mol Biol 2006
(Acute Disease...) :
These findings demonstrate that activation of protease activated receptor-2 with trypsin, which can be released after pancreatitis induction, positively regulates the transcript level of MIF, and increased
MIF results in exaggerated pulmonary expression of
TLR-4 , leading to the development of ALI with a subsequent infectious attack
Popa et al., Cytokine 2006
(Arthritis, Rheumatoid) :
Stimulation of DCs by
TLR4 ligands
resulted in higher
MIF production compared to immature DCs from healthy controls ( p < 0.002 ) and RA patients ( p < 0.002 )
West et al., Immunology 2008
(Vasculitis) :
Previously,
regulation of
TLR4 signalling by
MIF has been noted to be through control of TLR4 expression, but we observed that the actions of ISO-1 were mediated without changes in cell surface TLR4 levels
Wang et al., J Neuroimmunol 2013
(Guillain-Barre Syndrome) :
Significantly, silencing of
MIF attenuated the LOS induced up-regulation of
Toll-like receptor 4 (TLR4) and translocation of NF-?B into the nucleus ; we also observed the up-regulation of IL-12p40, TNF-a, IL-6, CXCL8 and CCL5 in GBS monocytes with LOS stimulus ; and siRNA-MIF overrided the effects of LOS on the production of the TNF-a, IL-6, and CXCL8