Gene interactions and pathways from curated databases and text-mining

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MIF — TLR4

Text-mined interactions from Literome

Nishihira et al., Nihon rinsho. Japanese journal of clinical medicine 2004 (Sepsis) : Recently, it was found that Toll-like receptor 4 could be regulated by MIF , suggesting its involvement in the innate immunity
Ohkawara et al., Histochem Cell Biol 2006 : In this study, we investigated the effect of MIF on the expression of TLR4 , a receptor that recognizes lipopolysaccharide, in colon using MIF-deficient mice ... Our results suggest that MIF affects the expression of TLR4 in mouse colon under both normal and colitic conditions
Matsuda et al., Am J Respir Cell Mol Biol 2006 (Acute Disease...) : These findings demonstrate that activation of protease activated receptor-2 with trypsin, which can be released after pancreatitis induction, positively regulates the transcript level of MIF, and increased MIF results in exaggerated pulmonary expression of TLR-4 , leading to the development of ALI with a subsequent infectious attack
Popa et al., Cytokine 2006 (Arthritis, Rheumatoid) : Stimulation of DCs by TLR4 ligands resulted in higher MIF production compared to immature DCs from healthy controls ( p < 0.002 ) and RA patients ( p < 0.002 )
West et al., Immunology 2008 (Vasculitis) : Previously, regulation of TLR4 signalling by MIF has been noted to be through control of TLR4 expression, but we observed that the actions of ISO-1 were mediated without changes in cell surface TLR4 levels
Wang et al., J Neuroimmunol 2013 (Guillain-Barre Syndrome) : Significantly, silencing of MIF attenuated the LOS induced up-regulation of Toll-like receptor 4 (TLR4) and translocation of NF-?B into the nucleus ; we also observed the up-regulation of IL-12p40, TNF-a, IL-6, CXCL8 and CCL5 in GBS monocytes with LOS stimulus ; and siRNA-MIF overrided the effects of LOS on the production of the TNF-a, IL-6, and CXCL8