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MAPK15 — MMP13

Text-mined interactions from Literome

Mengshol et al., Nucleic Acids Res 2001 (MAP Kinase Signaling System) : Using chondrocytic cells, we previously determined that IL-1 induced a strong MMP-13 transcriptional response that requires p38 MAPK , JNK and the transcription factor NF-kappaB
Onodera et al., J Biol Chem 2002 : Similarly, a selective mitogen activated protein kinase ( MAPK ) kinase ( MEK)1/2 inhibitor ( PD98059 ) and c-jun/activator protein (AP)-1 inhibitor ( curcumin ) suppressed MMP-13 mRNA up-regulation induced by MIF
Zaragoza et al., Mol Pharmacol 2002 : Activation of the mitogen activated protein kinase extracellular signal regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells
Dai et al., Ann Rheum Dis 2005 (Arthritis...) : In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor ... In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3, and MMP-13 , which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Rossa et al., Matrix Biol 2005 (MAP Kinase Signaling System) : MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts ... Reporter gene experiments using stable cell lines harboring 660-bp sequence of the murine Mmp-13 proximal promoter indicated that transcriptional mechanisms were at least partially involved in this negative regulation of Mmp-13 expression by p38 MAPK and upstream MKK3/6
Morquette et al., Arthritis Rheum 2006 (Osteoarthritis) : In isolated OA chondrocytes, HNE inhibited the expression of CII and tissue inhibitor of metalloproteinases 1 and induced MMP-13 mainly through activation of p38 MAPK
Popov et al., J Biol Chem 2006 (Liver Cirrhosis...) : p38 mitogen activated protein kinase ( p38 MAPK ) and nuclear factor kappaB(NFkappaB) pathways were activated by HAL, and specific inhibitors of p38 MAPK and NFkappaB dose dependently inhibited MMP-13 induction
Song et al., Endocrinology 2007 (Breast Neoplasms) : In noncancer cells, IGF-I initiates a linear process involving activation of the IGF-I receptor (IGF-IR) and matrix metalloproteinases ( MMP ) , release of heparin binding epidermal growth factor ( HB-EGF ), and activation of EGF receptor (EGFR) dependent MAPK
d'Abusco et al., Arthritis Res Ther 2007 (MAP Kinase Signaling System) : These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : Among them, the expression of MMP1, MMP3, MMP9 and MMP10 was MAPK dependent
Ding et al., Osteoarthritis Cartilage 2008 : To define the role of mitogen activated protein ( MAP ) kinases in fibronectin fragment ( Fn-f ) mediated matrix metalloproteinase ( MMP ) upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin ( Fn ), which is inactive in terms of cartilage damage
Tan et al., Carcinogenesis 2009 (Bone Neoplasms...) : RGD peptide, alphavbeta3 monoclonal antibody and mitogen activated protein kinase ( MEK ) inhibitors ( PD98059 and U0126 ) but not RAD peptide inhibited the Cyr61 induced increase of the migration and MMP-13 upregulation of chondrosarcoma cells
Kimura et al., J Pharmacol Sci 2009 (Osteoarthritis) : An ERK-MAPK pathway inhibitor ( U0126 ), but not a p38 kinase inhibitor ( SB203580 ) or a JNK inhibitor ( SP600125 ), also selectively inhibited IL-1beta induced MMP-13 production in HAC
Hong et al., J Dermatol Sci 2009 : GS-HCl differentially down-regulates COX-2 and MMP-13 expression in the IL-1beta- or PMA treated human skin fibroblasts via the p38 MAPK independent COX-2 translational inhibition and the p38 MAPK dependent MMP-13 transcriptional suppression, respectively
Santibáñez et al., FEBS Lett 2010 : Furthermore, MMP9 production was MAPK dependent , as the MEK inhibitor PD98059 decreased TGF-beta1 induced MMP9 expression and secretion in Q61LRac1 expressing cells
Long et al., Osteoarthritis Cartilage 2010 (Inflammation...) : p38gamma mitogen activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation
Chen et al., Invest New Drugs 2011 (Breast Neoplasms) : The MAPK inhibitors effectively prevented the loss of MMP and apoptosis induced by protoapigenone
You et al., Mol Biol Rep 2011 : All the MAPK inhibitors slightly enhanced cell growth inhibition, death and MMP ( d?m ) loss, and increased ROS levels in PG-treated HeLa cells
Cui et al., Biochem Biophys Res Commun 2012 (Neoplasm Invasiveness) : Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on MAPK activation, MMP2 induction and invasiveness in tumor cells
Nakashima et al., Biochem Biophys Res Commun 2012 (Osteoarthritis) : Both p38 mitogen activated protein kinase ( MAPK ) and nuclear factor-?B ( NF-?B ) inhibitors also suppressed the increases in mRNA expression and protein production of MMP-13 and VEGF
Lee et al., J Dermatol Sci 2013 : In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen activated protein kinase ( MAPK ), ATF-2, and c-Jun, and MMP expression