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EGF — MMP14

Text-mined interactions from Literome

Reddy et al., Int J Cancer 1999 (Breast Neoplasms...) : In contrast, when SKBR-3 cells were exposed to MEK inhibitor ( PD 98059 ) or MAPK inhibitors ( Apigenin or MAPK antisense phosphorothioate oligodeoxynucleotides ), EGF induced cell proliferation, MMP-9 induction and invasion through reconstituted basement membrane were significantly reduced
Sundareshan et al., Prostate 1999 (Adenocarcinoma...) : Induction of the MMP , matrilysin, by epidermal growth factor (EGF) was investigated in a human prostate cancer cell line
Huang et al., Br J Pharmacol 1999 (Neoplasm Metastasis) : 8. This study demonstrates that the inhibitory effects of Lu and Qu, and the stimulatory effects of EGF , on tumour cell proliferation, cellular protein phosphorylation, and MMP secretion may be mediated at least partly through EGFR
Domeij et al., Eur J Oral Sci 2002 (MAP Kinase Signaling System) : In addition, MMP-1 and MMP-3 production, induced by IL-1beta, TNFalpha or EGF , was strongly reduced by the presence of the glucocorticoid dexamethasone
Van Meter et al., Neuro Oncol 2004 (Glioma) : Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor mediated signaling in gliomas ... EGF stimulation of glioma cell lines resulted in a 2- to 4-fold increase in MT1-MMP mRNA levels ... Furthermore, the MT1-MMP induction by EGF was prevented by pretreatment with the EGFR-specific tyrphostin inhibitor AG1478 ... Similarly, treatment with the phosphatidylinositol 3-kinase inhibitor LY294002 prevented the induction of MT1-MMP protein by EGF stimulation
Vesey et al., Kidney Int 2005 (Calcium Signaling...) : These responses which are dependent on its protease activity appear not to be mediated by PAR-1 activation, the autocrine action of thrombin induced TGF-beta1 secretion, MMP activation, or EGF receptor transactivation
Ahmed et al., Am J Physiol Cell Physiol 2006 (Cell Transformation, Neoplastic) : EGF withdrawal resulted in a more epithelial morphology and reversal of the EGF induced activation of signaling pathways and pro-MMP activity
Cowden Dahl et al., Mol Cancer Res 2007 (Neoplasm Invasiveness...) : Additionally, inhibition of PEA3 expression via short interfering RNA reduced the EGF induction of MMP-9 and MMP-14 gene expression by 92 % and 50 %, respectively, and impaired EGF stimulated tumor cell invasion
Yu et al., Cytotechnology 2009 : Matrine significantly reduced the invasion, MMP-9/MMP-2 activation , Akt phosphorylation, nuclear factor kappaB p-65 expression and DNA binding activity, and mRNA levels of MMP-9, MMP-2, EGF and VEGFR1 in MDA-MB-231 cells
Zhang et al., Int J Gynecol Cancer 2009 (Carcinoma...) : We showed here that EGF induced the expression of MT1-MMP and inhibited the expression of MMP-2 at both the mRNA and protein levels ... Our results suggest that EGF receptor up-regulated the expression of MT1-MMP and down-regulated the synthesis of MMP-2 through the mitogen activated protein kinase/extracellular signal regulated kinase pathway while concomitantly transmitting a mild positive regulatory signal to the expression of MMP-2 via the PI3-K/AKT pathway in SiHa cells
Ouyang et al., Cancer Res 2010 : This difference in the activation patterns of MT1-MMP and Src in response to EGF is further confirmed using an optimized MT1-MMP biosensor capable of being rapidly cleaved by MT1-MMP
Pan et al., Invest Ophthalmol Vis Sci 2011 : Hypertonicity induced EGF receptor (EGFR) transactivation was suppressed by preincubating HCECs with capsazepine, matrix metalloproteinase 1 (MMP1) inhibitor TIMP-1, broad-spectrum MMP inhibitor GM 6001, heparin bound (HB)-EGF inhibitor CRM 197, or EGFR inhibitor AG 1478
Hwang et al., Mol Nutr Food Res 2011 (Fibrosarcoma...) : Capsaicin decreased the EGF induced expression of MMP-9, MMP-2 , and MT1-MMP, but did not alter TIMP-1 and TIMP-2 levels
Ueda et al., Int J Cancer 1997 (Carcinoma, Squamous Cell...) : We investigated the effects of epidermal growth factor (EGF) and transforming growth factor (TGF)-alpha on migration, invasion and matrix metalloproteinase ( MMP ) expression of uterine cervical-carcinoma SKG-IIIb cells, and whether these growth factors affect pyrimidine-nucleoside-phosphorylase ( PyNPase ) activity and 5'-deoxy-5-fluorouridine ( 5'-dFUrd ) sensitivity of tumor cells